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Titolo:
ENDOTHELIUM-DEPENDENT RELAXATION IN RESPONSE TO ADENOSINE-DIPHOSPHATEIS IMPAIRED UNDER POOR RUNOFF CONDITIONS IN THE CANINE FEMORAL-ARTERY
Autore:
KOMORI K; ISHII T; MAWATARI K; ODASHIRO T; ITOH H; OKADOME K; SUGIMACHI K;
Indirizzi:
KYUSHU UNIV,FAC MED,DEPT SURG 2 FUKUOKA 812 JAPAN
Titolo Testata:
The Journal of surgical research
fascicolo: 3, volume: 58, anno: 1995,
pagine: 302 - 306
SICI:
0022-4804(1995)58:3<302:ERIRTA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRALUMINAL VELOCITY PROFILE; VASCULAR SMOOTH-MUSCLE; AUTOGENOUS VEIN GRAFTS; AGGREGATING PLATELETS; PROSTACYCLIN PRODUCTION; INTIMAL HYPERPLASIA; RELAXING FACTOR; SHEAR-STRESS; FLOW; HYPERCHOLESTEROLEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
K. Komori et al., "ENDOTHELIUM-DEPENDENT RELAXATION IN RESPONSE TO ADENOSINE-DIPHOSPHATEIS IMPAIRED UNDER POOR RUNOFF CONDITIONS IN THE CANINE FEMORAL-ARTERY", The Journal of surgical research, 58(3), 1995, pp. 302-306

Abstract

To examine whether poor distal runoff conditions of the canine femoral artery modulates endothelium-dependent relaxations, we developed a poor distal runoff limb in the canine right femoral artery (poor runoffgroup). The left femoral artery was used as a control. Endothelium-dependent responses were examined in vitro. The rings of femoral artery were obtained from dogs pretreated with 6 weeks of poor distal runoff. In the control, flow rate and tau-variation were 79.1 ml/min and 214.2 dynes/cm(2), respectively. In the poor runoff group, the flow rate and tau-variation were 27.4 ml/min and 52.7 dynes/cm(2). There were significant differences between the two groups. In the rings taken from the control group contracted with norepinephrine, adenosine diphosphate(ADP) and A23187 caused endothelium-dependent relaxations. In the poor runoff group, the endothelium-dependent relaxations in response to ADP were impaired, while A23187 caused comparable endothelium-dependentrelaxations. Direct relaxations in response to sodium nitroprusside were comparable between the two groups. These experiments indicate thatunder poor runoff conditions, the endothelium-dependent relaxations to ADP are impaired without changing the properties of the smooth muscle cells. This dysfunction of the endothelium under conditions of abnormal flow may accelerate a loss of late patency of the reconstructed arteries. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:03:10