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Titolo:
EFFECT OF THE COMBINATION OF INTERFERON-ALPHA AND STAVUDINE ON FRIEND-VIRUS INFECTIONS IN (B10.A X A.BY)F-1 MICE
Autore:
SIDWELL RW; WARREN RP; OKLEBERRY K; BURGER RA; MORREY JD;
Indirizzi:
UTAH STATE UNIV,INST ANTIVIRAL RES,DEPT ANIM DAIRY & VET SCI LOGAN UT84322
Titolo Testata:
The Journal of infectious diseases
, volume: 171, anno: 1995, supplemento:, 2
pagine: 93 - 98
SICI:
0022-1899(1995)171:<93:EOTCOI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; GENETICALLY DEFINED MICE; COMPLEX INFECTION; POTENT; HIV; MODEL; D4T; 2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE; ZIDOVUDINE; ANALOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
R.W. Sidwell et al., "EFFECT OF THE COMBINATION OF INTERFERON-ALPHA AND STAVUDINE ON FRIEND-VIRUS INFECTIONS IN (B10.A X A.BY)F-1 MICE", The Journal of infectious diseases, 171, 1995, pp. 93-98

Abstract

The anti-Friend leukemia virus (FLV) effects of interferon-alpha-A/D (IFN-alpha) and 2',3'-didehydro-2',3'-dideoxythymidine (stavudine) used alone and in combination were examined in Mus dunni cells using a checkerboard-type experiment design. Strong antiviral synergy and a suggested cytotoxic synergy were seen. In two experiments to evaluate the effect of combining therapy with IFN-alpha and stavudine against FLV disease in the hybrid mouse strain (B10.A X A.By) F-1, which is a strong producer of cytotoxic T cells, the drug combination resulted in better inhibition of FLV disease than did either drug used alone. Combination therapy inhibited splenomegaly, splenic virus infectious centers, plasma virus, and the virus-induced increase in hematocrit to a greater degree than did either drug alone. These data indicate that combination therapy with stavudine and IFN-alpha is effective in the treatmentof murine retrovirus infections and may be of value in the treatment of human AIDS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 11:46:01