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Titolo:
ECHOCARDIOGRAPHIC LEFT-VENTRICULAR SYSTOLIC FUNCTION AND VOLUMES IN YOUNG-ADULTS - DISTRIBUTION AND FACTORS INFLUENCING VARIABILITY
Autore:
WONG ND; GARDIN JM; KUROSAKI T; ANTONCULVER H; SIDNEY S; ROSEMAN J; GIDDING S;
Indirizzi:
UNIV CALIF IRVINE,DIV CARDIOL,PREVENT CARDIOL PROGRAM,C240 MED SCI 1 IRVINE CA 92717 UNIV CALIF IRVINE,DEPT MED,DIV EPIDEMIOL IRVINE CA 92717 KAISER PERMANENTE MED CTR,DIV RES OAKLAND CA 00000 CARDIA COORDINATING CTR BIRMINGHAM AL 00000 CHILDRENS MEM HOSP CHICAGO IL 60614
Titolo Testata:
The American heart journal
fascicolo: 3, volume: 129, anno: 1995,
pagine: 571 - 577
SICI:
0002-8703(1995)129:3<571:ELSFAV>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; HEART-DISEASE; MASS; RADIONUCLIDE; CARDIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
N.D. Wong et al., "ECHOCARDIOGRAPHIC LEFT-VENTRICULAR SYSTOLIC FUNCTION AND VOLUMES IN YOUNG-ADULTS - DISTRIBUTION AND FACTORS INFLUENCING VARIABILITY", The American heart journal, 129(3), 1995, pp. 571-577

Abstract

Low left ventricular ejection fraction (LVEF), a measure of global systolic left ventricular dysfunction, is associated with an increased risk of recurrent coronary events or death in persons with cardiac disease. There are few data on the distribution of resting LVEF and component volumes in healthy young adults or on any association of LVEF withcoronary risk factors. LVEF and left ventricular end-diastolic and end-systolic volumes (LVEDV and LVESV, respectively) were measured by two-dimensional echocardiography in 1782 men and women 23 to 35 years old without self-reported heart disease (other than mitral valve prolapse, n = 53) who were participants in the multicenter Coronary Artery Risk Development in Young Adults study. Factors analyzed as potential contributors to LVEF, LVEDV, and LVESV included age, gender, race, bloodpressure, alcohol use, current smoking, family history of myocardial infarction, total and high-density lipoprotein cholesterol concentrations, obesity, reported physical activity, and fitness as assessed by treadmill exercise testing. LVEF was lower in men (mean 62.6%, SD 5.7%)than in women (mean 63.9%, SD 5.7%) (p < 0.01) but did not differ significantly between black and white subjects. Ninety percent of subjects had an LVEF between 53% and 71%. LVEDV and LVESV were >25% greater in men than in women. From multivariate analysis, male gender, history of hypertension, and current smoking were each positively and independently associated with an approximately 1% lower LVEF. Body surface area, a family history of premature myocardial infarction, and treadmill workload 150 time were positively related, whereas total skinfold thickness was negatively related to LVEDV and LVESV. In addition, systolicblood pressure was positively related and diastolic blood pressure and total cholesterol concentration negatively related to LVEDV, whereastreadmill performance measured in metabolic equivalents (METS) and current smoking were positively related and age negatively related to LVESV. These results suggest that LVEF in healthy young adults is maintained over a limited range and that its variability not substantially associated with coronary risk factors. Determination of whether differences in LVEF, LVESV, and LVEDV in young adults influence future cardiovascular risk and whether obesity and other factors express any effecton risk through differences in LVESV and LVEDV will require longitudinal follow-up studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:10:49