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Titolo:
CYTOSTATIC FACTOR INACTIVATION IS INDUCED BY A CALCIUM-DEPENDENT MECHANISM PRESENT UNTIL THE 2ND CELL-CYCLE IN FERTILIZED BUT NOT IN PARTHENOGENETICALLY ACTIVATED MOUSE EGGS
Autore:
ZERNICKAGOETZ M; CIEMERYCH MA; KUBIAK JZ; TARKOWSKI AK; MARO B;
Indirizzi:
UNIV PARIS 07,CNRS,INST JACQUES MONOD,DEPT DEV BIOL,TOUR 43-2 PL JUSSIEU F-75005 PARIS FRANCE UNIV WARSAW,INST ZOOL,DEPT EMBRYOL PL-00927 WARSAW POLAND UNIV PARIS 07,CNRS,INST JACQUES MONOD,DEPT DEV BIOL F-75005 PARIS FRANCE
Titolo Testata:
Journal of Cell Science
, volume: 108, anno: 1995,
parte:, 2
pagine: 469 - 474
SICI:
0021-9533(1995)108:<469:CFIIIB>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
METAPHASE-II ARREST; PROTOONCOGENE PRODUCT; MEIOTIC ARREST; XENOPUS EGGS; HAMSTER EGGS; OOCYTES; MOS; REQUIREMENT; INTERPHASE; INCREASES;
Keywords:
MOUSE OOCYTE; CSF; CYTOSTATIC FACTOR; MPF; MATURATION PROMOTING FACTOR; CELL CYCLE; SPERM; PARTHENOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M. Zernickagoetz et al., "CYTOSTATIC FACTOR INACTIVATION IS INDUCED BY A CALCIUM-DEPENDENT MECHANISM PRESENT UNTIL THE 2ND CELL-CYCLE IN FERTILIZED BUT NOT IN PARTHENOGENETICALLY ACTIVATED MOUSE EGGS", Journal of Cell Science, 108, 1995, pp. 469-474

Abstract

Cytostatic factor (CSF) is an activity responsible for the metaphase II arrest in vertebrate oocytes, This activity maintains a high level of maturation promoting factor (MPF) in the oocyte and both activitiesare destroyed after fertilization or parthenogenetic activation. To study some of the characteristics of the mechanism involved in MPF and CSF destruction, we constructed hybrid cells between metaphase LT arrested oocytes and early embryos obtained after fertilization or artificial activation, We found that the behavior of hybrid cells differed depending upon the type of oocyte activation, Initially, the reaction ofboth types of hybrid cells was similar, the nuclear envelope broke down and chromatin condensation was induced. However, while metaphase IIoocytes fused with parthenogenetic eggs remained arrested in M-phase,the oocytes fused with fertilized eggs underwent activation and passed into interphase, This ability of fertilized eggs to induce oocyte activation was still present at the beginning,but not at the end of the second embryonic cell cycle, Oocyte activation induced by fusion with a fertilized egg could be prevented when calcium was chelated by BAPTA. Thus, element(s) of the mechanism involved in calcium release triggered by a sperm component at fertilization remain(s) active until the second cell cycle and is (are) inactivated before the end of the 2-cellstage.

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Documento generato il 27/11/20 alle ore 22:32:45