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Titolo:
PHYSIOLOGICAL DETERMINANTS OF HYPERREACTIVITY TO STRESS IN BORDERLINEHYPERTENSION
Autore:
SHERWOOD A; HINDERLITER AL; LIGHT KC;
Indirizzi:
DUKE UNIV,MED CTR,DEPT PSYCHIAT & BEHAV SCI,BOX 3119 DURHAM NC 27710 UNIV N CAROLINA,DEPT MED CHAPEL HILL NC 00000 UNIV N CAROLINA,DEPT PSYCHIAT CHAPEL HILL NC 00000
Titolo Testata:
Hypertension
fascicolo: 3, volume: 25, anno: 1995,
pagine: 384 - 390
SICI:
0194-911X(1995)25:3<384:PDOHTS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLD PRESSOR TEST; BLOOD-PRESSURE; PLASMA-CATECHOLAMINES; RACIAL-DIFFERENCES; SINUS ARRHYTHMIA; RESPONSIVENESS; RESPONSES; REACTIVITY; STABILITY;
Keywords:
HYPERTENSION, BORDERLINE; RECEPTORS, ADRENERGIC; STRESS; BLOOD PRESSURE; CARDIAC OUTPUT; VASCULAR RESISTANCE; CATECHOLAMINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A. Sherwood et al., "PHYSIOLOGICAL DETERMINANTS OF HYPERREACTIVITY TO STRESS IN BORDERLINEHYPERTENSION", Hypertension, 25(3), 1995, pp. 384-390

Abstract

Blood pressure hyperreactivity during stress is characteristic of borderline hypertension in white men. The present study evaluated the hemodynamic basis of this hyperreactivity and assessed its physiological basis in terms of sympathetic nervous system function. Cardiovascular adjustments to an aversive reaction time test were compared with theseof the forehead cold presser test, representing stressors that elicitactive behavioral responses in contrast to passive tolerance of aversive stimulation. As anticipated, blood pressure increases were greaterin 12 borderline hypertensive men compared with 21 age-matched normotensive men during the active reaction time stressor but not during thepassive cold presser test. The presser hyperreactivity in borderline hypertensives was associated with excessive rises in plasma epinephrine and norepinephrine, leading to greater increases in cardiac output, despite evidence that the cardiac beta-adrenergic receptors in these subjects were downregulated compared with those of normotensive subjects. During the cold pressor test, borderline hypertension was associated with greater increases in systemic vascular resistance, which, in the presence of normal baroreoeptor reflex function, led to an attenuation of cardiac output, thus producing no greater net effect on blood pressure than seen in normotensive subjects. Evidence of vascular hypertrophy in the borderline hypertensive subjects was considered to account for their vascular hyperreactivity to cold presser stimulation. Collectively, the observations in this study further support the view thatthe early stages of hypertension in white men are characterized by sympathetic nervous system hyperreactivity, but only in association withtasks that elicit active behavioral coping responses. The extent to which these responses are elicited by typical daily events may be an important determinant of whether borderline hypertension matures to its established form, which displays hemodynamic characteristics dominatedby vascular structural changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:29:47