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Titolo:
MECHANICAL ALTERNANS AND THE FORCE-FREQUENCY-RELATIONSHIP IN FAILING RAT HEARTS
Autore:
NARAYAN P; MCCUNE SA; ROBITAILLE PML; HOHL CM; ALTSCHULD RA;
Indirizzi:
OHIO STATE UNIV,DEPT MED BIOCHEM,333 HAMILTON HALL,1645 NEIL AVE COLUMBUS OH 43210 OHIO STATE UNIV,DEPT MED BIOCHEM COLUMBUS OH 43210 OHIO STATE UNIV,DEPT FOOD SCI & TECHNOL COLUMBUS OH 43210 OHIO STATE UNIV,DEPT RADIOL COLUMBUS OH 43210
Titolo Testata:
Journal of Molecular and Cellular Cardiology
fascicolo: 1, volume: 27, anno: 1995,
pagine: 523 - 530
SICI:
0022-2828(1995)27:1<523:MAATFI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACELLULAR CALCIUM TRANSIENTS; SARCOPLASMIC-RETICULUM; MYOCARDIUM; FERRET; MUSCLE; CARDIOMYOCYTES; HYPERTENSION; HYPERTROPHY; STAIRCASE; FAILURE;
Keywords:
SARCOPLASMIC RETICULUM; THAPSIGARGIN; ALTERNANS; HEART FAILURE; FORCE-FREQUENCY RELATIONSHIP; SHHF/MCC-FA(CP) RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
P. Narayan et al., "MECHANICAL ALTERNANS AND THE FORCE-FREQUENCY-RELATIONSHIP IN FAILING RAT HEARTS", Journal of Molecular and Cellular Cardiology, 27(1), 1995, pp. 523-530

Abstract

We examined contractile performance in perfused ventricles from normal rats and from SHHF/Mcc-fn(cp) rats with end-stage heart failure. Changes in pacing frequency from 3 to 5 Hz evoked a complex response in normal rat myocardium, The first beat after a switch to 5 Hz was extremely weak, but each successive beat was stronger until force exceeded the 3 Hz steady state value by similar to 30%. Force then gradually declined to a new steady state where developed pressure was depressed butrate-pressure product was slightly greater than that at 3 Hz. Ply contrast, in failing SHHF/Mcc-fa(cp) hearts, an increase in pacing frequency from 3 to 5 Hz did not increase force development, Instead, the isovolumic left Ventricles exhibited mechanical alternans. This alternation between weak and strong beats was abolish-ed by 1 mM caffeine but restored by its washout. Inhibition of SR Ca2+ accumulation by 50-500 nM thapsigargin in normal ventricles did not evoke alternans when pacing frequencies were increased, The results indicate that mechanical alternans in failing rat hearts is due to altered reactions of the sarcoplasmic reticulum, but a decreased rate of Ca2+ accumulation is not the primary cause.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:22:44