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Titolo:
SEROTONIN RECEPTOR-BINDING IN A COLONY MODEL OF CHRONIC SOCIAL STRESS
Autore:
MCKITTRICK CR; BLANCHARD DC; BLANCHARD RJ; MCEWEN BS; SAKAI RR;
Indirizzi:
ROCKEFELLER UNIV,NEUROENDOCRINOL LAB,BOX 165,1230 YORK AVE NEW YORK NY 10021 UNIV HAWAII,DEPT ANAT & REPROD BIOL HONOLULU HI 96822 UNIV HAWAII,DEPT PSYCHOL HONOLULU HI 96822 UNIV PENN,DEPT ANIM BIOL PHILADELPHIA PA 00000
Titolo Testata:
Biological psychiatry
fascicolo: 6, volume: 37, anno: 1995,
pagine: 383 - 393
SICI:
0006-3223(1995)37:6<383:SRIACM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN TRYPTOPHAN-HYDROXYLASE; RAT-BRAIN; REPEATED IMMOBILIZATION; DEXAMETHASONE TREATMENT; DORSAL HIPPOCAMPUS; GENE-EXPRESSION; FEMALE RATS; 5-HT1A; DEPRESSION; ADRENALECTOMY;
Keywords:
STRESS; SEROTONIN; 5-HT1A RECEPTOR; 5-HT2 RECEPTOR; DOMINANCE; SUBORDINATION; CORTICOSTERONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
C.R. Mckittrick et al., "SEROTONIN RECEPTOR-BINDING IN A COLONY MODEL OF CHRONIC SOCIAL STRESS", Biological psychiatry, 37(6), 1995, pp. 383-393

Abstract

Male rats housed in mixed-sex groups quickly established dominance hierarchies in which subordinates appeared severely stressed. Subordinate rats had elevated basal corticosterone (CORT) levels relative to dominants and individually housed controls. Several subordinates had blunted CORT responses to a novel stressor, leading to the classification of subordinates as either stress-responsive or nonresponsive, Binding to 5-HT1A receptors was reduced in stress-responsive subordinates compared to controls throughout hippocampus and dentate gyrus, Decreased binding was observed in nonresponsive subordinates only in CA3 of hippocampus, In addition, 5-HT1A binding was decreased in CAI, CA3, and CA4in dominants compared to controls, Binding to 5-HT2 receptors was increased in parietal cortex in both responsive and nonresponsive subordinates compared to controls, No changes were observed in binding to 5-HT(1)A receptors, These results are discussed in the context of regulation of the serotonergic system by stress and glucocorticoids and possible relevance to the pathophysiology of depression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:37:07