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Titolo:
THE ROLE FOR HOST-IMMUNE FACTORS IN THE IN-VIVO ANTIVIRAL EFFECTS OF TUMOR-NECROSIS-FACTOR
Autore:
LIDBURY BA; RAMSHAW IA; SAMBHI SK;
Indirizzi:
ROYAL NEWCASTLE HOSP,AUSTRALIAN INST MUCOSAL IMMUNOL,DAVID MADDISON BLDG,POB 418 NEWCASTLE NSW 2300 AUSTRALIA AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DIV CELL BIOL CANBERRA ACT 2601 AUSTRALIA
Titolo Testata:
Cytokine
fascicolo: 2, volume: 7, anno: 1995,
pagine: 157 - 164
SICI:
1043-4666(1995)7:2<157:TRFHFI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT VACCINIA VIRUS; NATURAL-KILLER CELLS; INTERFERON-GAMMA; ECTROMELIA VIRUS; FACTOR-ALPHA; ACTIVITY INVIVO; T-CELLS; INFECTION; MICE; CYTOKINES;
Keywords:
TNF; VACCINIA VIRUS; AB 301; CBA; H MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
B.A. Lidbury et al., "THE ROLE FOR HOST-IMMUNE FACTORS IN THE IN-VIVO ANTIVIRAL EFFECTS OF TUMOR-NECROSIS-FACTOR", Cytokine, 7(2), 1995, pp. 157-164

Abstract

This report examines the host-immune response to vaccinia virus in mice exposed to tumour necrosis factor (TNF), Exposure to TNF was done via two approaches; (1) mice were treated with TNF in complex with a specific anti-TNF antibody (Ab 301) which enhances the antiviral efficacy of this cytokine, prior to vaccinia virus (VV) infection; and (2) mice were infected with a recombinant VV which encodes the murine TNF gene (VV-HA-TNF), The antiviral effect induced by TNF plus Ab 301 in CBA/H mice was not sensitive to sub-lethal gamma irradiation, indicating that a proliferative immune tell population was not responsible for the observed attenuated VV growth, This was further evidenced by NK celland CTL studies which showed, when compared to controls, that TNF plus Ab 301 treated animals had decreased spleen NK cell and CTL activities, This suggests that a non-specific factor, effective earlier than day 2 postinfection, was responsible for the restriction of VV growth, To further investigate this possibility, mice were treated with eitherthe TNF/Ab 301 regimen, or infected with VV-HA-TNF, and their peritoneal exudate cells (PEG) examined during early VV infection, Control recombinant VV infection resulted in an increase in neutrophil numbers, and TNF/Ab 301 treatment before infection did not increase this further, VV-HA-TNF infection of mice, however, induced a massive but transient increase in the number of neutrophils, suggesting that this;cell population was important to the in vivo restriction of VV-HA-TNF growth.

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Documento generato il 29/11/20 alle ore 08:58:26