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Titolo:
THE EUKARYOTIC COFACTOR FOR THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) REV PROTEIN, EIF-5A, MAPS TO CHROMOSOME 17P12-P13 - 3 EIF-5A PSEUDOGENES MAP TO 10Q23.3, 17Q25, AND 19Q13.2
Autore:
STEINKASSERER A; JONES T; SHEER D; KOETTNITZ K; HAUBER J; BEVEC D;
Indirizzi:
SANDOZ GMBH,RES INST,BRUNNERSTR 59 A-1235 VIENNA AUSTRIA IMPERIAL CANC RES FUND LONDON WC2A 3PX ENGLAND
Titolo Testata:
Genomics
fascicolo: 3, volume: 25, anno: 1995,
pagine: 749 - 752
SICI:
0888-7543(1995)25:3<749:TECFTH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSLATION INITIATION-FACTOR; HYPUSINE; LOCALIZATION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
A. Steinkasserer et al., "THE EUKARYOTIC COFACTOR FOR THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) REV PROTEIN, EIF-5A, MAPS TO CHROMOSOME 17P12-P13 - 3 EIF-5A PSEUDOGENES MAP TO 10Q23.3, 17Q25, AND 19Q13.2", Genomics, 25(3), 1995, pp. 749-752

Abstract

The eukaryotic initiation factor 5A (eIF-5A) has been identified as an essential cofactor for the HIV-1 transactivator protein Rev. Rev plays a key role in the complex regulation of HIV-1 gene expression and thereby in the generation of infectious virus particles. Expression of eIF-5A is vital for Rev function, and inhibition of this interaction leads to a block of the viral replication cycle. In humans, four different eIF-5A genes have been identified. One codes for the eIF-5A protein and the other three are pseudogenes. Using a panel of somatic rodent-human cell hybrids in combination with fluorescence in situ hybridization analysis, we show that the four genes map to three different chromosomes. The coding eIF-5A gene (EIF5A) maps to 17p12-p13, and the three pseudogenes EIF5AP1, EIF5AP2, and EIF5AP3 map to 10q23.3, 17q25, and 19q13.2, respectively. This is the first localization report for a eukaryotic cofactor for a regulatory HIV-1 protein. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 14:19:59