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Titolo:
IMMEDIATE AND EARLY FOLLOW-UP RESULTS OF PULSE-SPRAY THROMBOLYSIS IN PATIENTS WITH PERIPHERAL ISCHEMIA
Autore:
YUSUF SW; WHITAKER SC; GREGSON RHS; WENHAM PW; HOPKINSON BR; MAKIN GS;
Indirizzi:
UNIV NOTTINGHAM HOSP,DEPT VASC SURG NOTTINGHAM NG7 2UH ENGLAND UNIV NOTTINGHAM HOSP,DEPT RADIOL NOTTINGHAM NG7 2UH ENGLAND
Titolo Testata:
British Journal of Surgery
fascicolo: 3, volume: 82, anno: 1995,
pagine: 338 - 340
SICI:
0007-1323(1995)82:3<338:IAEFRO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAARTERIAL THROMBOLYSIS; ISCHEMIA; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
S.W. Yusuf et al., "IMMEDIATE AND EARLY FOLLOW-UP RESULTS OF PULSE-SPRAY THROMBOLYSIS IN PATIENTS WITH PERIPHERAL ISCHEMIA", British Journal of Surgery, 82(3), 1995, pp. 338-340

Abstract

Pulse spray thrombolysis is a technique of accelerated peripheral thrombolysis which has been evaluated in 38 patients, 29 with threatened limb viability and nine with a viable but critically ischaemic limb. The median length of occlusion was 26.5 (range 3-65) cm. The lytic agent used was recombinant tissue plasminogen activator (rtPA), injected manually via a pulse spray catheter at a concentration of 0.33 mg/ml and a bolus size of 0.2 ml. The median total dose of rtPA was 18 (range 5-35) mg. Patency and flow were completely restored in 34 of 38 patients and clinical success at 30 days was maintained in 27 of 38. The median lysis time was 120 (range 35-1125) min, compared with a median duration of 1545 (range 42-5760) min in 120 consecutive patients previously treated with conventional low-dose infusion thrombolysis using rtPA. This represents a 12-fold reduction in lysis time (P < 0.001). The overall estimated cumulative limb salvage rate for the 38 patients who entered the study was 84 per cent and the cumulative patency rate for the 34 patients in whom patency was restored was 74 per cent at 18 months follow-up. Pulse spray thrombolysis rapidly restores patency with good limb salvage at 30 days; the benefit is sustained even in patients with limbs at immediate risk of irreversible ischaemic injury who are not considered suitable for conventional thrombolysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 14:33:08