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Titolo:
IMMUNOTHERAPY IN LIVER-TUMORS .3. A NEW EXPERIMENTAL-MODEL OF METASTATIC LIVER-TUMORS FROM COLORECTAL-CARCINOMA FOR CYTOKINE THERAPY
Autore:
LIU DL; RADNELL M; SVANBERG K; SEIFERT J;
Indirizzi:
KAMNARSVAGEN 3A 117 S-22646 LUND SWEDEN LUND UNIV,DEPT SURG & ONCOL LUND SWEDEN TONGII MED UNIV,TONGII HOSP,DEPT SURG,TUMOR & IMMUNOL LAB WUHAN PEOPLES R CHINA CHRISTIAN ALBRECHTS UNIV KIEL,INST EXPTL SURG RES KIEL GERMANY
Titolo Testata:
Cancer letters
fascicolo: 2, volume: 88, anno: 1995,
pagine: 211 - 219
SICI:
0304-3835(1995)88:2<211:IIL.AN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC METASTASES; RESECTION; CANCER;
Keywords:
CYTOKINES; HEPATIC ARTERY LIGATION; HEPATOCELLULAR CARCINOMA; IMMUNOTHERAPY; INTERFERON-ALPHA; INTERLEUKIN-2; METASTATIC LIVER TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Liu et al., "IMMUNOTHERAPY IN LIVER-TUMORS .3. A NEW EXPERIMENTAL-MODEL OF METASTATIC LIVER-TUMORS FROM COLORECTAL-CARCINOMA FOR CYTOKINE THERAPY", Cancer letters, 88(2), 1995, pp. 211-219

Abstract

A new model of metastatic liver tumors in Wistar/Furth rats is introduced. A colorectal adenocarcinoma cell line (LDLX40) induced by 1,2-dimethylhydrazine was injected through one of the branches of the ileal mesenteric vein to develop metastatic liver tumors in rats. On day 30 after the inoculation of tumor cells, micrometastases were detected under microscopy in all animals that received tumor inoculation. Macrometastases in 87.7% of animals were found by either the tumor staining test or ultrasonography. No extrahepatic tumor developed in this tumor model. To observe the effects of different treatment strategies on metastatic liver tumors, 35 animals were randomly divided into four groups, Group I served as control. Group II underwent hepatic artery ligation (HAL), Group III received intraportal administration of recombinantinterleukin-2 (rIL-2) and interferon-alpha (IFN-alpha). Group IV had intraportal medication of rIL-2 and IFN-alpha + HAL (the IIH protocol), Results indicated that rapid tumor growth was seen in the control tumors. HAL produced little response to metastatic liver tumors as compared to the control group (P > 0.05). The combined application of rIL-2and IFN-alpha showed an improved result, with 22% of tumor growth inhibition or regression (P < 0.05 compared to the control group). Twenty-eight percent of tumor growth restraint or regression was found in the group treated with the IIH protocol (P < 0.05 compared to the control group), We conclude that this new experimental model of metastatic liver tumors is reproducible, and that the IIH protocol is effective inthe treatment of metastatic liver tumors in rats, These beneficial effects from the III-I protocol may be introduced into patients with metastatic liver tumors.

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Documento generato il 21/09/20 alle ore 15:28:03