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Titolo:
PHARMACOKINETIC AND THERAPEUTIC OUTCOME IN MELANOMA-CELLS, OF THE ADMINISTRATION OF SYMMETRICAL AND ASYMMETRIC CATIONIC PHOTOSENSITIZERS
Autore:
HAYLETT AK; ROSS S; TRUSCOTT TG; MOORE JV;
Indirizzi:
CHRISTIE HOSP NATL HLTH SERV TRUST,PATERSON INST CANC RES MANCHESTER M20 9BX LANCS ENGLAND PAISLEY UNIV,DEPT CHEM PAISLEY PA1 2BE RENFREW SCOTLAND UNIV KEELE,DEPT CHEM KEELE ST5 5BG STAFFS ENGLAND
Titolo Testata:
Cancer letters
fascicolo: 2, volume: 88, anno: 1995,
pagine: 191 - 199
SICI:
0304-3835(1995)88:2<191:PATOIM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOTODYNAMIC THERAPY; PHOTOFRIN-II; DENSITY LIPOPROTEINS; PIGMENTED MELANOMA; CELLULAR-UPTAKE; TUMOR-UPTAKE; PORPHYRINS; RADIATION; SERUM; LASER;
Keywords:
PHOTODYNAMIC THERAPY; MELANOMA; CATIONIC PHOTOSENSITIZERS; CLONOGENIC ASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Haylett et al., "PHARMACOKINETIC AND THERAPEUTIC OUTCOME IN MELANOMA-CELLS, OF THE ADMINISTRATION OF SYMMETRICAL AND ASYMMETRIC CATIONIC PHOTOSENSITIZERS", Cancer letters, 88(2), 1995, pp. 191-199

Abstract

The response of melanoma cell lines to a range of novel cationic photosensitizers based on either a protoporphyrin or a mesotetra(4-carboxylphenyl)porphine molecule, has been examined. The drugs varied in terms of either their symmetry or their side chain configuration, The effect of these variables on drug uptake and photodynamic cell kill were tested, The absorption wavelengths for the drugs were measured and a shift to the red was seen in the presence of cells. Drug uptake was measured and the cationic sensitizers had a relatively high uptake when compared to anionic HpD. The efficiency of the drugs in causing cell kill was expressed in terms of clonogenic cell survival. The asymmetric photosensitizers were more efficient in destroying mouse and human melanoma cells than the clinically used anionic HpD, which was in turn more efficient than the symmetric sensitizers tested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 14:48:43