Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MERCURIC CHLORIDE-INDUCED PROGRAMMED CELL-DEATH OF A MURINE T-CELL HYBRIDOMA .2. OPPOSITE EFFECT OF INTERLEUKIN-2 AND INTERLEUKIN-4
Autore:
PRIGENT P; PONCET P; ATEN J; BLANPIED C; CHAND A; FEVRIER M; DRUET P; HIRSCH F;
Indirizzi:
HOP BROUSSAIS,INSERM,U28,96 RUE DIDOT F-75014 PARIS FRANCE HOP BROUSSAIS,INSERM,U28 F-75014 PARIS FRANCE UNIV AMSTERDAM,ACAD MED CTR,DEPT PATHOL 1105 AZ AMSTERDAM NETHERLANDS
Titolo Testata:
Cellular immunology
fascicolo: 1, volume: 161, anno: 1995,
pagine: 107 - 111
SICI:
0008-8749(1995)161:1<107:MCPCOA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED AUTOIMMUNITY; MONOCLONAL-ANTIBODY; IL-2 PROTECTS; LYMPHOCYTES-T; GROWTH-FACTOR; B-CELL; APOPTOSIS; ANTIGEN; MICE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
P. Prigent et al., "MERCURIC CHLORIDE-INDUCED PROGRAMMED CELL-DEATH OF A MURINE T-CELL HYBRIDOMA .2. OPPOSITE EFFECT OF INTERLEUKIN-2 AND INTERLEUKIN-4", Cellular immunology, 161(1), 1995, pp. 107-111

Abstract

In susceptible animals evidence is accumulating for a primary role for Th2 cells in the course of HgCl2-induced autoimmunity, and for a contribution of Th1 cells in the self-regulated phase of this disease. Wehave reported that incubation of 2B4.11 T cell hybridoma with HgCl2 induced programmed cell death. This paper shows that recombinant IL-2 significantly diminished HgCl2-induced 2B4.11 cell death. Although no effect was observed upon incubation with exogenous IL-4, we observed a significant protection by adding an anti-IL-4 monoclonal antibody to the culture. Accordingly, by RT-PCR we found the presence of IL-2 receptor-encoding mRNA, and by cytofluorometry, the expression of the protein was detected only after exposure to HgCl2. Moreover, upon HgCl2 treatment, 2B4.11 cells were induced to produce IL-4. Altogether these findings showed that cytokine environment, IL-2, IL-4 otherwise definingthe Th1/Th2 dichotomy, in conjunction with a chemical may differentially influence the fate of cell populations, death or survival. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:13:34