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Titolo:
SEVERITY OF MULTIPLE ORGAN FAILURE (MOF) BUT NOT OF SEPSIS CORRELATESWITH IRREVERSIBLE PLATELET DEGRANULATION
Autore:
GAWAZ M; FATEHMOGHADAM S; PILZ G; GURLAND HJ;
Indirizzi:
TECH UNIV MUNICH,KLINIKUM RECHTS ISAR,MED KLIN 1,ISMANINGERSTR 22 D-80165 MUNICH GERMANY UNIV MUNICH,KLINIKUM GROSSHADERN,MED KLIN 1 D-81377 MUNICH GERMANY
Titolo Testata:
Infection
fascicolo: 1, volume: 23, anno: 1995,
pagine: 16 - 23
SICI:
0300-8126(1995)23:1<16:SOMOF(>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT RESPIRATORY-DISTRESS; ACTIVATED PLATELETS; SEPTIC SHOCK; APACHE-II; MEMBRANE; THROMBOCYTOPENIA; THROMBOSPONDIN; PATHOGENESIS; AGGREGATION; NEUTROPHILS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M. Gawaz et al., "SEVERITY OF MULTIPLE ORGAN FAILURE (MOF) BUT NOT OF SEPSIS CORRELATESWITH IRREVERSIBLE PLATELET DEGRANULATION", Infection, 23(1), 1995, pp. 16-23

Abstract

Multiple hemostatic changes occur in sepsis and multiple organ failure (MOF). To evaluate the role of platelets in patients with sepsis andMOF, we examined changes in surface glycoproteins on circulating platelets of 14 patients with suspected sepsis and MOF. The severity of sepsis and MOF was assessed by the Elebute and APACHE II scoring systems, respectively. Using flow cytometric techniques and platelet specificmonoclonal antibodies, platelet surface expression of fibrinogen receptor on GPIIb-IIIa, of von Willebrand Factor receptor GPIb, and of granule glycoproteins (thrombospondin (TSP), GMP-140, GP53) was measured,Plasma membrane expression of GPIIb-IIIa and GPIb on circulating platelets was not affected by sepsis or MOF. Septic patients, however, showed a significantly elevated fibrinogen receptor activity (LIBS1 expression) (p<0.05) that correlated with severity of disease (r=0.597, p=0.043), No significant change in surface expression,ression of granule glycoproteins (TSP, GMP-140, GP53) was noted in septic patients, In contrast, degranulation of granule glycoproteins was significantly elevated in MOF (p<0.05) which correlated well with severity of MOF (GMP-140, r=0.611, p=0.013; TSP, r=0.643, p=0.026). We speculate that platelets in sepsis circulate in a hyperaggregable but still reversible statethat results in increased risk of microthrombotic events, In the course of the disease, irreversible platelet degranulation of adhesion molecules occurs that may play an important role in the development of MOF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 12:32:04