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Titolo:
POSITRON EMISSION TOMOGRAPHY MEASURES OF BENZODIAZEPINE BINDING IN ALZHEIMERS-DISEASE
Autore:
MEYER M; KOEPPE RA; FREY KA; FOSTER NL; KUHL DE;
Indirizzi:
UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED,DIV NUCL MED,1500 E MED CTR,BIG505K ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED,DIV NUCL MED ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT NEUROL ANN ARBOR MI 48109
Titolo Testata:
Archives of neurology
fascicolo: 3, volume: 52, anno: 1995,
pagine: 314 - 317
SICI:
0003-9942(1995)52:3<314:PETMOB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GABA-IMMUNOREACTIVE NEURONS; HUMAN CEREBRAL-CORTEX; SENILE DEMENTIA; RECEPTOR DISTRIBUTION; HUNTINGTONS-DISEASE; C-11 FLUMAZENIL; HUMAN-BRAIN; NEUROTRANSMITTER; RADIOLIGAND; NEOCORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Meyer et al., "POSITRON EMISSION TOMOGRAPHY MEASURES OF BENZODIAZEPINE BINDING IN ALZHEIMERS-DISEASE", Archives of neurology, 52(3), 1995, pp. 314-317

Abstract

Objective: To evaluate the integrity of neurons and neuropil in metabolically affected association cortices of patients with Alzheimer's disease by measuring central benzodiazepine binding sites with the use of positron emission tomography. Design: In patients with Alzheimer's disease, we determined the cerebral distribution of flumazenil tagged with carbon 11 ([C-11]flumazenil), a ligand that binds to the gamma-aminobutyric acid A (GABA(A)) receptor complex, and the distribution of fludeoxyglucose tagged with fluorine 18 fludeoxyglucose F 18), a measure of local cerebral glucose metabolism. Tracer kinetic analysis was applied to quantify data in regions of interest. These data were compared with those of normal control subjects. Subjects: Patients with probable Alzheimer's disease ([C-11] flumazenil, n=13; fludeoxyglucose F 18, n=11) and normal elderly control subjects ([C-11]flumazenil, n=6; fludeoxyglucose F 18, n=10). Results: Significant decreases of the [C-11]flumazenil transport rate were found in hypometabolic parietal and temporal association cortices, but [C-11]flumazenil binding was not significantly decreased. Conclusions: When measured in living patients, association cortical benzodiazepine binding sites are relatively preserved, suggesting structurally intact cortical neuropil underlying the glucose hypometabolism identified in Alzheimer's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:03:33