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Titolo:
SOME SPECIFIC CLINICAL-FEATURES DIFFERENTIATE MULTIPLE SYSTEM ATROPHY(STRIATONIGRAL VARIETY) FROM PARKINSONS-DISEASE
Autore:
COLOSIMO C; ALBANES A; HUGHES AJ; DEBRUIN VMS; LEES AJ;
Indirizzi:
INST NEUROL,PARKINSONS DIS SOC,BRAIN TISSUE BANK,1 WAKEFIELD ST LONDON WC1N 1PJ ENGLAND INST NEUROL,PARKINSONS DIS SOC,BRAIN TISSUE BANK LONDON WC1N 1PJ ENGLAND MIDDLESEX HOSP,DEPT NEUROL LONDON W1N 8AA ENGLAND UNIV CATTOLICA SACRO CUORE,IST NEUROL ROME ITALY
Titolo Testata:
Archives of neurology
fascicolo: 3, volume: 52, anno: 1995,
pagine: 294 - 298
SICI:
0003-9942(1995)52:3<294:SSCDMS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; DOPAMINERGIC RESPONSIVENESS; DEGENERATION; TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
C. Colosimo et al., "SOME SPECIFIC CLINICAL-FEATURES DIFFERENTIATE MULTIPLE SYSTEM ATROPHY(STRIATONIGRAL VARIETY) FROM PARKINSONS-DISEASE", Archives of neurology, 52(3), 1995, pp. 294-298

Abstract

Objective: The clinical recognition of multiple system atrophy (MSA) in patients presenting with parkinsonian signs is difficult. We attempted to verify the predictive value of some pointers that are used in clinical practice. Design: Sixteen consecutive patients with pathologically confirmed MSA who presented with a parkinsonian syndrome over an 8-year period were studied retrospectively, and their clinical features were analyzed in detail. Setting: Parkinson's Disease Society, BrainTissue Bank, Institute of Neurology, London, England. Patients: Sixteen patients with pathologically proven MSA who presented with parkinsonian syndrome in the first 3 years since disease onset. Methods: Clinical Features that were analyzed inr eluded;he rapidity of disease progression, the relative symmetry of symptom onset, the presence or absence of tremor at initial presentation, the therapeutic response to levodopa and the associated presence of autonomic dysfunction. Fourteen ofthe 16 patients also had a computed tomographic scan of the brain performed. The frequency of selected items in MSA was compared with that found in 20 pathologically confirmed cases of Parkinson's disease and 16 pathologically confirmed cases of progressive supranuclear palsy (Steele-Richardson-Olszewski disease). Results: It was found that a probability scale based on five selected items discriminated MSA with a pure parkinsonian presentation from Parkinson's disease, but not from progressive supranuclear palsy. Patients affected by the latter disorder, however, commonly presented with additional clinical features (supranuclear vertical down-gaze palsy, axial dystonia, and cognitive impairment), which helped to differentiate it from MSA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:37:59