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Titolo:
FOLLOW-UP OF COGNITIVE-FUNCTIONING IN PATIENTS WITH SMALL-CELL LUNG-CANCER
Autore:
VANOOSTERHOUT AGM; BOON PJ; HOUX PJ; TENVELDE GPM; TWIJNSTRA A;
Indirizzi:
UNIV LIMBURG HOSP,DEPT NEUROL,P DEBYELAAN 25,POSTBOX 5800 6202 AZ MAASTRICHT NETHERLANDS UNIV LIMBURG HOSP,DEPT PSYCHOL MED 6202 AZ MAASTRICHT NETHERLANDS UNIV LIMBURG HOSP,DEPT PSYCHIAT 6202 AZ MAASTRICHT NETHERLANDS UNIV LIMBURG HOSP,DEPT PULMONOL 6202 AZ MAASTRICHT NETHERLANDS
Titolo Testata:
International journal of radiation oncology, biology, physics
fascicolo: 4, volume: 31, anno: 1995,
pagine: 911 - 914
SICI:
0360-3016(1995)31:4<911:FOCIPW>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROPHYLACTIC CRANIAL IRRADIATION; LONG-TERM SURVIVORS; BRAIN IRRADIATION; ABNORMALITIES; NEUROTOXICITY; CHEMOTHERAPY; TOMOGRAPHY; CARCINOMA; INJURY;
Keywords:
SMALL CELL LUNG CANCER; COGNITIVE IMPAIRMENT; PSYCHOMETRIC TESTING; NEUROTOXICITY; CHEMOTHERAPY; PROPHYLACTIC CRANIAL IRRADIATION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A.G.M. Vanoosterhout et al., "FOLLOW-UP OF COGNITIVE-FUNCTIONING IN PATIENTS WITH SMALL-CELL LUNG-CANCER", International journal of radiation oncology, biology, physics, 31(4), 1995, pp. 911-914

Abstract

Purpose: Study of the course of possible treatment-related cognitive impairment in patients with small cell lung cancer, Methods and Materials: Thirty-two consecutive patients with small cell lung cancer underwent successive neurologic and neuropsychologic examinations until 5 months after prophylactic cranial irradiation, and in their pretherapeutic condition were compared to matched controls, Patients with brain metastases were excluded from this study, Results: Neurologic examination revealed central nervous system (CNS) abnormalities only in the 14 patients with brain metastases, In the remaining patients, neuropsychologic tests showed clear differences between the pretherapeutic performance of patients and that of matched controls (p < 0.001), but no significant deterioration either during or after therapy (0.1 < p < 0.8),Conclusion: The difference between the pretherapeutic performance of patients and that of matched controls may indicate disease-related cognitive impairment. Within the observation period, no adverse effects of the used therapy were found, Our observations underline the importance of a pretherapeutic assessment in neurotoxicity research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:26:02