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Titolo:
THE INTRINSIC RADIOSENSITIVITY OF CERVICAL-CARCINOMA - CORRELATIONS WITH CLINICAL-DATA
Autore:
WEST CML; DAVIDSON SE; BURT PA; HUNTER RD;
Indirizzi:
CHRISTIE HOSP NATL HLTH SERV TRUST,PATERSON INST CANC RES,CANC RES CAMPAIGN MANCHESTER M20 9BX LANCS ENGLAND CHRISTIE HOSP NATL HLTH SERV TRUST,DEPT CLIN ONCOL MANCHESTER M20 9BXLANCS ENGLAND
Titolo Testata:
International journal of radiation oncology, biology, physics
fascicolo: 4, volume: 31, anno: 1995,
pagine: 841 - 846
SICI:
0360-3016(1995)31:4<841:TIROC->2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; UTERINE CERVIX; PROGNOSTIC-SIGNIFICANCE; RADIATION; RADIOTHERAPY; PLOIDY; CANCER; DNA; ADENOCARCINOMA; SURVIVAL;
Keywords:
PREDICTIVE ASSAYS; INTRINSIC RADIOSENSITIVITY; CARCINOMA OF THE CERVIX; PLOIDY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
C.M.L. West et al., "THE INTRINSIC RADIOSENSITIVITY OF CERVICAL-CARCINOMA - CORRELATIONS WITH CLINICAL-DATA", International journal of radiation oncology, biology, physics, 31(4), 1995, pp. 841-846

Abstract

Purpose: The aims of the work were to study the intrinsic radiosensitivity of tumor biopsies from patients with cervical carcinoma and to correlate the data with information on patient age, disease stage, differentiation status, tumor volume, and tumor ploidy. Methods and materials: Radiosensitivity was assessed for 145 tumors in vitro as surviving fraction at 2 Gy (SF2) using a clonogenic assay. Results: Although the clonogens in tumors classified as Stage I or II tended to be more radiosensitive than in Stage III or IV disease, the difference was not statistically significant (p > 0.15), There was also no significant difference in the intrinsic radiosensitivity of well, moderately, or poorly differentiated tumors or between squamous cell carcinoma and adenocarcinoma (p > 0.53). There was no correlation between patient age andtumor radiosensitivity (p = 0.49). Large volume (greater than or equal to 4 cm) disease was more radioresistant than small volume (< 4 cm) disease, but the difference was not significant (p = 0.08). Finally, diploid tumors tended to be more radioresistant than aneuploid tumors (p = 0.07). Conclusion: The intrinsic radiosensitivity of cervix tumorsis independent of disease stage, tumor grade, and patient age, Weak trends, however, were observed of increased tumor radioresistance for large volume disease and diploid tumors, suggesting that tumor SF2 may not be a completely independent parameter.

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Documento generato il 09/07/20 alle ore 20:08:56