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Titolo:
NITROUS-OXIDE PRODUCES A BIPHASIC EFFECT ON OPIATE-INDUCED MUSCLE RIGIDITY IN THE RAT
Autore:
CHANG NJ; WEINGER MB; DYCK JB;
Indirizzi:
VET AFFAIRS MED CTR,3350 LA JOLLA VILLAGE DR SAN DIEGO CA 92161 VET AFFAIRS MED CTR SAN DIEGO CA 92161 UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL SAN DIEGO CA 00000
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 3, volume: 50, anno: 1995,
pagine: 351 - 358
SICI:
0091-3057(1995)50:3<351:NPABEO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED MUSCULAR RIGIDITY; ALFENTANIL; FENTANYL; ANALGESIA; KETAMINE; INVOLVEMENT; ANESTHESIA; REVERSAL; DRUGS;
Keywords:
OPIATES; ALFENTANIL; NITROUS OXIDE; MUSCLE RIGIDITY; SKELETAL MUSCLE; ELECTROMYOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
N.J. Chang et al., "NITROUS-OXIDE PRODUCES A BIPHASIC EFFECT ON OPIATE-INDUCED MUSCLE RIGIDITY IN THE RAT", Pharmacology, biochemistry and behavior, 50(3), 1995, pp. 351-358

Abstract

Muscle rigidity is a side effect of potent opiate agonists like alfentanil. Older clinical studies suggested that nitrous oxide (N2O) augments opiate rigidity, but this has never been rigorously examined in ananimal model. Sixty-two Wistar rats were placed in a Plexiglas box through which fresh gas flowed at 4 l/min. Muscle rigidity was assessed using gastrocnemius electromyographic (EMG) activity. Rats were exposed to either 60% N2O in O-2 or 100% O-2, EMG was measured for 10 min, alfentanil (0, 50, 175, or 350 mu g/kg) was administered intravenously,and data were collected for 45 min. Alfentanil produced a dose-dependent increase in EMG activity in both O-2 and N2O groups (p < 0.001). At 1 min postalfentanil, N2O caused significantly more rigidity than 100% O-2 (p < 0.001). However, beginning at 5 min, N2O attenuated both the magnitude and the duration of rigidity. Study of a separate group of animals breathing 30% O-2 demonstrated that N2O's attenuating effecton alfentanil rigidity was not due to reduced inspired oxygen concentration. These results are described by a theoretical model of the pharmacodynamic interactions of alfentanil and nitrous oxide.

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Documento generato il 19/01/20 alle ore 20:05:11