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Titolo:
EFFECT OF THE 5-HT3 ANTAGONIST ONDANSETRON ON VOLUNTARY ETHANOL INTAKE IN RATS AND MICE MAINTAINED ON A LIMITED ACCESS PROCEDURE
Autore:
TOMKINS DM; LE AD; SELLERS EM;
Indirizzi:
ADDICT RES FDN,33 RUSSELL ST TORONTO ON M5S 2S1 CANADA
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 117, anno: 1995,
pagine: 479 - 485
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; RECEPTOR ANTAGONIST; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; EXTRACELLULAR DOPAMINE; ALCOHOL PREFERENCE; MESOLIMBIC SYSTEM; ICS 205-930; BRAIN; CONSUMPTION;
Keywords:
ETHANOL INTAKE; WATER INTAKE; WISTAR RATS; C57BL/6 MICE; CHRONIC ADMINISTRATION; BLOOD ETHANOL CONCENTRATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Tomkins et al., "EFFECT OF THE 5-HT3 ANTAGONIST ONDANSETRON ON VOLUNTARY ETHANOL INTAKE IN RATS AND MICE MAINTAINED ON A LIMITED ACCESS PROCEDURE", Psychopharmacology, 117(4), 1995, pp. 479-485

Abstract

The effect of the 5-HT3 antagonist ondansetron on ethanol self-administration was examined in a limited access paradigm. Acute administration of ondansetron (0.01 and 0.1 mg/kg) reduced ethanol intake in male Wistar rats by 35%, whilst water intake was unaffected. Both a lower (0.001 mg/kg) and higher dose (1 mg/kg) of ondansetron failed to modifyethanol consumption. Ondansetron did not, however, alter the pharamacokinetic profile of an orally administered dose of ethanol (1 g/kg) over the same dose range. To examine the generality of these findings and to determine if tolerance would develop to the suppressant effects of ondansetron on ethanol intake, male C57BL/6 mice were treated with ondansetron (0.001, 0.01 and 0.1 mg/kg) over 22 days, 30 min prior to scheduled access to ethanol. Both 0.01 and 0.1 mg/kg doses reduced ethanol intake; however, water intake was not altered by either dose. Thisfinding confirms and extends the generality of the effects of 5-HT3 receptor antagonists on ethanol intake across different species and different paradigms of ethanol consumption. More importantly, the presentstudy shows that the reduction in ethanol intake induced by ondansetron was maintained even after a prolonged period of treatment and is not due to an alteration in the absorption or metabolism of ethanol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 18:12:47