Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE NEUROENDOCRINOLOGICAL PROFILE OF ROXINDOLE, A DOPAMINE AUTORECEPTOR AGONIST, IN SCHIZOPHRENIC-PATIENTS
Autore:
GRUNDER G; WETZEL H; HILLERT A; JOCHUM E; HIEMKE C; BENKERT O;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55131 MAINZ GERMANY
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 117, anno: 1995,
pagine: 472 - 478
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; GROWTH-HORMONE; PROLACTIN SECRETION; OVARIECTOMIZED RATS; LUTEINIZING-HORMONE; 3-PPP ENANTIOMERS; MAJOR DEPRESSION; HUMAN PITUITARY; GH SECRETION; SOMATOSTATIN;
Keywords:
ROXINDOLE; DOPAMINE AUTORECEPTOR AGONISM; 5-HT REUPTAKE INHIBITION; 5-HT1A AGONISM; PROLACTIN; TSH; GH; TRH STIMULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
G. Grunder et al., "THE NEUROENDOCRINOLOGICAL PROFILE OF ROXINDOLE, A DOPAMINE AUTORECEPTOR AGONIST, IN SCHIZOPHRENIC-PATIENTS", Psychopharmacology, 117(4), 1995, pp. 472-478

Abstract

Roxindole is a potent autoreceptor-selective dopamine agonist with additional properties as a serotonin reuptake inhibitor and 5-HT1A agonist. In order to get more insight into its mode of action in various psychiatric populations, we evaluated the effects of subchronic roxindole treatment on pituitary and adrenal hormone secretion, i.e. release of prolactin, thyroid stimulating hormone (TSH), growth hormone (GH), luteinizing hormone (LH), and cortisol. Fifteen schizophrenic patients with positive and negative symptomatology, respectively, were treated with roxindole for 28 days. Both basal and thyrotropin releasing hormone (TRH) -induced prolactin secretion diminished significantly to 26.4% and 22.8% of baseline levels, respectively, under roxindole. Basal GH secretion was insignificantly elevated by 89%, whereas GH levels increased nearly 3-fold after stimulation by TRH. TSH levels decreased insignificantly to 57.5% of baseline levels, while TRH-induced TSH release was not affected by subchronic roxindole. Roxindole treatment influenced neither LH secretion nor cortisol release. Our results indicate that roxindole's dopaminergic actions might prevail over its serotonergic effects, at least as far as the regulation of anterior pituitary hormone secretion is concerned.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 08:19:59