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Titolo:
OBESITY, ALCOHOL, AND TOBACCO AS RISK-FACTORS FOR CANCERS OF THE ESOPHAGUS AND GASTRIC CARDIA - ADENOCARCINOMA VERSUS SQUAMOUS-CELL CARCINOMA
Autore:
VAUGHAN TL; DAVIS S; KRISTAL A; THOMAS DB;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,PROGRAM EPIDEMIOL MP474,1124 COLUMBIA STSEATTLE WA 98104 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195
Titolo Testata:
Cancer epidemiology, biomarkers & prevention
fascicolo: 2, volume: 4, anno: 1995,
pagine: 85 - 92
SICI:
1055-9965(1995)4:2<85:OAATAR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-MASS INDEX; UNITED-STATES; BARRETTS-ESOPHAGUS; SMOKING; TRENDS; MEN; POPULATION; PREVALENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Vaughan et al., "OBESITY, ALCOHOL, AND TOBACCO AS RISK-FACTORS FOR CANCERS OF THE ESOPHAGUS AND GASTRIC CARDIA - ADENOCARCINOMA VERSUS SQUAMOUS-CELL CARCINOMA", Cancer epidemiology, biomarkers & prevention, 4(2), 1995, pp. 85-92

Abstract

Adenocarcinomas of the esophagus and gastric cardia were once rare. However, for unknown reasons, their incidence has been increasing rapidly over the past 15 years in the United States and parts of Western Europe. In contrast, the incidence of esophageal squamous cell carcinomas has remained relatively constant. To investigate possible reasons for these diverging incidence rates we analyzed data from two population-based case-control studies of cancers of the esophagus and gastric cardia that were conducted among male and female residents of western Washington between 1983 and 1990. Information on body mass index, cigarette use, alcohol intake, and other possible risk factors was collectedvia personal interviews with 404 cases or their next of kin (including 298 adenocarcinomas and 106 squamous cell carcinomas) and 724 controls identified by random digit dialing. Use of alcohol and cigarettes were significant risk factors for both histological types. The increasein risk for current smokers of 80 or more pack-years compared to nonsmokers was substantially higher for squamous cell cancer [odds ratio (OR) = 16.9; 95% confidence interval (CI) = 4.1-69.1] than for adenocarcinoma (OR = 3.4; 95% Cl = 1.4-8.0), as was the increase for persons who typically drank 21 or more drinks/week compared to those who drank <7/week (OR = 9.5; 95% CI = 4.1-22.3 versus OR = 1.8; 95% CI = 1.1-3.1) For squamous cell carcinoma,,body mass index was inversely associated with risk, whereas for adenocarcinoma, the highest risk was observedamong persons who were in the highest decile of body mass index (OR =1.9; 95% CI = 1.1-3.2). The risks associated with alcohol and tobaccouse appeared to be similarly elevated for adenocarcinomas arising in the gastric cardia and esophagus; however, there was some evidence that obesity was more strongly associated with esophageal adenocarcinoma (OR = 2.5; 95% CI = 1.2-5.0 for persons in the highest decile). Together, obesity, cigarette smoking, and alcohol use accounted for approximately 50% of the adenocarcinoma cases diagnosed in the Seattle area over the period 1983-1990. In comparison, cigarette smoking and alcohol intake alone accounted for 87% of the squamous cell cases. Additional studies should focus on the role of obesity to determine whether adenocarcinoma risk varies by the pattern of fat deposition and by patternsof weight over a lifetime. Intervention trials aimed at reducing weight among persons at high risk of esophageal adenocarcinoma, such as persons with Barrett's metaplasia, are also indicated to establish the causal role of obesity and to determine the usefulness of dietary intervention in reducing rates of neoplastic progression to cancer.

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Documento generato il 27/10/20 alle ore 10:37:02