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Titolo:
ROLES OF DIVALENT-CATIONS AND PH IN MECHANISM OF ACTION OF NITROXOLINE AGAINST ESCHERICHIA-COLI STRAINS
Autore:
PELLETIER C; PROGNON P; BOURLIOUX P;
Indirizzi:
CTR ETUD PHARMACEUT,DEPT MICROBIOL & IMMUNOL,5 RUE JB CLEMENT F-92296CHATENAY MALABRY FRANCE CTR ETUD PHARMACEUT,CHIM ANALYT LAB 2 F-92296 CHATENAY MALABRY FRANCE
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 3, volume: 39, anno: 1995,
pagine: 707 - 713
SICI:
0066-4804(1995)39:3<707:RODAPI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNESIUM-ALUMINUM HYDROXIDE; BACTERIAL ADHERENCE; ANTIMICROBIAL AGENTS; INVITRO ACTIVITY; CELLS; SUPPLEMENTATION; QUINOLONES; INHIBITION; ABSORPTION; REDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
C. Pelletier et al., "ROLES OF DIVALENT-CATIONS AND PH IN MECHANISM OF ACTION OF NITROXOLINE AGAINST ESCHERICHIA-COLI STRAINS", Antimicrobial agents and chemotherapy, 39(3), 1995, pp. 707-713

Abstract

The antibacterial activity of nitroxoline (NIT), an antibiotic used in the treatment of acute or recurrent urinary tract infections caused by Escherichia coli, is decreased in the presence of Mg2+ and Mn2+ butnot Ca2+, In order to elucidate the interaction between this drug andthe divalent cations, spectrophotometric studies based on the naturalabsorption of the nitroxoline moiety were conducted, In the presence of the divalent metal ions, a shift in the NIT A(448) suggested the formation of drug-ion complexes, for which the stability followed the order Mn2+ > Mg2+ > Ca2+, A clear correlation was found between the chelating property and antibacterial activity of NIT; both were pH dependent, A convenient colorimetric method for the determination of NIT uptake by bacterial cells was also developed, Uptake was energy independent and showed biphasic kinetics: a rapid association with cells and then a slower increase in cell-associated NIT which reached a plateau, NIT uptake was reduced in the presence of magnesium, The implications ofmetal ion complexation and pH on the clinical efficacy of NIT are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:33:40