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Titolo:
EFFECTS OF MONOCLONAL-ANTIBODY COMBINED WITH GANCICLOVIR OR -1[3-HYDROXY-(2-PHOSPHONYLMETHOXY)-PROPYL]CYTOSINE AGAINST MURINE CYTOMEGALOVIRUS INFECTIONS IN CELL-CULTURE AND IN SEVERE COMBINED IMMUNODEFICIENT MICE
Autore:
SMEE DF; SUGIYAMA ST; SIDWELL RW; BARNETT BB;
Indirizzi:
UTAH STATE UNIV,DEPT ANIM DAIRY & VET SCI LOGAN UT 84322 UTAH STATE UNIV,DEPT BIOL LOGAN UT 84322
Titolo Testata:
Chemotherapy
fascicolo: 2, volume: 41, anno: 1995,
pagine: 141 - 148
SICI:
0009-3157(1995)41:2<141:EOMCWG>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS; 9-(1,3-DIHYDROXY-2-PROPOXYMETHYL)GUANINE; TRANSPLANTATION; PROPHYLAXIS; RECIPIENTS; ACYCLOVIR; EFFICACY; DISEASE;
Keywords:
MONOCLONAL ANTIBODY; GANCICLOVIR; IMMUNODEFICIENT MICE; MURINE CYTOMEGALOVIRUS; ANTIVIRAL; 1-[3-HYDROXY-(2-PHOSPHONYLMETHOXY)-PROPYL]CYTOSINE (HPMPC); SEVERE COMBINED IMMUNODEFICIENT (SCID) MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
D.F. Smee et al., "EFFECTS OF MONOCLONAL-ANTIBODY COMBINED WITH GANCICLOVIR OR -1[3-HYDROXY-(2-PHOSPHONYLMETHOXY)-PROPYL]CYTOSINE AGAINST MURINE CYTOMEGALOVIRUS INFECTIONS IN CELL-CULTURE AND IN SEVERE COMBINED IMMUNODEFICIENT MICE", Chemotherapy, 41(2), 1995, pp. 141-148

Abstract

The effects of monoclonal antibody used in combination with ganciclovir (GCV) or -1-[3-hydroxy-(2-phosphonylmethoxy)propyl]cytosine (HPMPC)against murine cytomegalovirus (MCMV) were determined in vitro and invivo, in mice. The antibody and drug were added to cell cultures 24 hafter MCMV adsorption so as not to affect the initial infection rate. The antibody (at 1.25-20 mu g/ml) combined with GCV (0.3-5 mu M) or HPMPC (0.008-0.125 mu M) caused synergistic inhibition of virus yield in C127I cells. No toxic effect on cell growth in culture was observed at these antibody/drug combinations. The effects of antibody and GCV treatments were studied in MCMV-infected severe combined immunodeficient (SCID) mice. Antibody treatments (2.5 mg/kg/day) given by intraperitoneal injection every 3 days starting 24 h after virus inoculation extended survival time by 1 day relative to placebo-treated animals. Oncedaily, intraperitoneal treatments with GCV (25 and 50 mg/kg/day) for 7 days starting at 24 h after virus inoculation extended survival time9-11 days. The combination of antibody plus GCV was only slightly better than GCV alone, indicating an additive interaction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:08:24