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Titolo:
MASSIVE CELL-DEATH OF IMMATURE HEMATOPOIETIC-CELLS AND NEURONS IN BCL-X-DEFICIENT MICE
Autore:
MOTOYAMA N; WANG FP; ROTH KA; SAWA H; NAKAYAMA K; NAKAYAMA K; NEGISHI I; SENJU S; ZHANG Q; FUJII S; LOH DY;
Indirizzi:
WASHINGTON UNIV,SCH MED,HOWARD HUGHES MED INST ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,HOWARD HUGHES MED INST ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT MED ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PATHOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT BIOL MOLEC ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PHARMACOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DIV CARDIOVASC MED ST LOUIS MO 63110
Titolo Testata:
Science
fascicolo: 5203, volume: 267, anno: 1995,
pagine: 1506 - 1510
SICI:
0036-8075(1995)267:5203<1506:MCOIHA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROTUBULE-ASSOCIATED PROTEINS; MUTANT CHIMERIC MICE; B-CELL; GENE; APOPTOSIS; PROTOONCOGENE; MECHANISMS; EXPRESSION; MUTATION; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
N. Motoyama et al., "MASSIVE CELL-DEATH OF IMMATURE HEMATOPOIETIC-CELLS AND NEURONS IN BCL-X-DEFICIENT MICE", Science, 267(5203), 1995, pp. 1506-1510

Abstract

bcl-x is a member of the bcl-2 gene family, which may regulate programmed cell death. Mice were generated that lacked Bcl-x. The Bcl-x-deficient mice died around embryonic day 13. Extensive apoptotic cell death was evident in postmitotic immature neurons of the developing brain,spinal cord, and dorsal root ganglia. Hematopoietic cells in the liver were also apoptotic. Analyses of bcl-x double-knockout chimeric miceshowed that the maturation of Bcl-x-deficient lymphocytes was diminished. The life-span of immature lymphocytes, but not mature lymphocytes, was shortened. Thus, Bcl-x functions to support the viability of immature cells during the development oi the nervous and hematopoietic systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 12:56:46