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Titolo:
THE IN-VIVO METABOLIC PATTERN OF LOW-GRADE BRAIN GLIOMAS - A POSITRONEMISSION TOMOGRAPHIC STUDY USING F-18 FLUORODEOXYGLUCOSE AND C-11 L-METHYLMETHIONINE
Autore:
DERLON JM; PETITTABOUE MC; CHAPON F; BEAUDOUIN V; NOEL MH; CREVEUIL C; COURTHEOUX P; HOUTTEVILLE JP;
Indirizzi:
CTR CYCERON,CYCLOTRON BIOMED CAEN,CEA DSV,CNRS,INSERM,BLVD HENRI BECQUEREL,POB 5229 F-14074 CAEN FRANCE CTR ANTICANC FRANCOIS BACLESSE,DEPT RADIOL,UNITE RMN CAEN FRANCE CTR ANTICANC FRANCOIS BACLESSE,DEPT MED INFORMAT CAEN FRANCE CTR ANTICANC FRANCOIS BACLESSE,NEUROPATHOL LAB CAEN FRANCE CTR ANTICANC FRANCOIS BACLESSE,SERV NEUROCHIRURG CAEN FRANCE
Titolo Testata:
Neurosurgery
fascicolo: 2, volume: 40, anno: 1997,
pagine: 276 - 287
SICI:
0148-396X(1997)40:2<276:TIMPOL>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-11 L-METHIONINE; F-18 FLUORODEOXYGLUCOSE; FDG-PET; GLUCOSE; TUMORS; OLIGODENDROGLIOMA; ASTROCYTOMAS; GLIOBLASTOMA; CARMUSTINE; PREDICTION;
Keywords:
AMINO ACIDS METABOLISM; ASTROCYTOMAS; GLUCOSE METABOLISM; LOW-GRADE GLIOMAS; OLIGODENDROGLIOMAS; POSITRON EMISSION TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Derlon et al., "THE IN-VIVO METABOLIC PATTERN OF LOW-GRADE BRAIN GLIOMAS - A POSITRONEMISSION TOMOGRAPHIC STUDY USING F-18 FLUORODEOXYGLUCOSE AND C-11 L-METHYLMETHIONINE", Neurosurgery, 40(2), 1997, pp. 276-287

Abstract

OBJECTIVE: The object of the present study was to identify metabolic differences between low-grade astrocytomas and oligodendrogliomas and to improve their diagnosis and noninvasive assessment, because both types of tumors look very similar from the point of view of clinical andradiological data (as assessed by computed tomography and magnetic resonance imaging). METHODS: Before any aggressive treatment, 22 patients with primary low-grade gliomas (astrocytomas in 12 patients and oligodendrogliomas in 10) were investigated with positron emission tomography for both glucose metabolism (F-18-fluorodeoxyglucose) and amino acid uptake (C-11-L-methylmethionine). An original software that allows a full metabolic analysis of the tumor region of interest (defined from the T1-weighted magnetic resonance image) and compares tumor tissue uptake tracer concentrations with average healthy tissue values has been implemented for data processing. Heterogeneity of each individual tumor has been taken into account and was expressed in histograms, which provided data about the mean and also extreme and intermediate values of tracer concentrations and the way these values are distributed among the full tumor mass. RESULTS: It has been shown that both tumor types exhibit a glucose hypometabolism (slightly more pronounced with astrocytomas), whereas they strongly differ in methionine uptake, which is high in all oligodendrogliomas and either decreased, normal, or moderately increased in astrocytomas. This latter metabolic difference between both tumor populations may be partially explained by their different cell densities. CONCLUSION: This study suggests that despite similar radiological and clinical presentations, these two kinds of low-grade gliomas are metabolically different and could therefore have specific responses to different therapies. Moreover, their in vivo metabolic follow-up with positron emission tomography should rely on differentparameters, depending on their histological type; methionine uptake may be more relevant than glucose metabolism in the follow-up of oligodendrogliomas.

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Documento generato il 29/11/20 alle ore 03:32:36