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Titolo:
EVOLUTIONARY CORRELATION BETWEEN CONTROL REGION SEQUENCE AND RESTRICTION POLYMORPHISMS IN THE MITOCHONDRIAL GENOME OF A LARGE SENEGALESE MANDENKA SAMPLE
Autore:
GRAVEN L; PASSARINO G; SEMINO O; BOURSOT P; SANTACHIARABENERECETTI S; LANGANEY A; EXCOFFIER L;
Indirizzi:
UNIV GENEVA,DEPT ANTHROPOL,GENET & BIOMETRIE LAB,CP 511 CH-1211 GENEVA 24 SWITZERLAND UNIV GENEVA,DEPT ANTHROPOL,GENET & BIOMETRIE LAB CH-1211 GENEVA 24 SWITZERLAND UNIV MONTPELLIER 2,GENOME & POPULAT LAB,CNRS,URA 1493 MONTPELLIER FRANCE UNIV PAVIA,DIPARTIMENTO GENET & MICROBIOL I-27100 PAVIA ITALY MUSEE HOMME PARIS,CNRS,URA 49 PARIS FRANCE
Titolo Testata:
Molecular biology and evolution
fascicolo: 2, volume: 12, anno: 1995,
pagine: 334 - 345
SICI:
0737-4038(1995)12:2<334:ECBCRS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDONUCLEASE CLEAVAGE PATTERNS; HLA-DR POLYMORPHISM; DNA-SEQUENCES; HUMAN-POPULATIONS; HUMAN ORIGINS; DIFFERENTIATION; AFFINITIES; RADIATION;
Keywords:
AFRICA; MOLECULAR EVOLUTION; HOMO SAPIENS; MITOCHONDRIAL DNA; HUMAN EVOLUTION; POPULATION GENETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
L. Graven et al., "EVOLUTIONARY CORRELATION BETWEEN CONTROL REGION SEQUENCE AND RESTRICTION POLYMORPHISMS IN THE MITOCHONDRIAL GENOME OF A LARGE SENEGALESE MANDENKA SAMPLE", Molecular biology and evolution, 12(2), 1995, pp. 334-345

Abstract

We present here the first comparative analysis at the population level between Restriction Fragment Length Polymorphism (RFLP) and control region sequence polymorphism in a large and homogeneous Senegalese Mandenka sample. Eleven RFLP haplotypes and 60 different sequences are found in 119 individuals, revealing that a very high level of mtDNA diversity can be maintained in a small population. A sequence neighbor-joining tree and an analysis of molecular variance show that sequences associated with a given restriction haplotype are evolutionarily highly correlated: sequencing generally leads to the subtyping of RFLP haplotypes. Evolutionary relationships among RFLP haplotypes inferred from restriction site differences are in good agreement with those inferred from sequence data. A single difference is observed and is likely due to a single restriction homoplasy having occurred in the control region. Selective neutrality tests on both RFLP and sequence data accept the hypotheses of mtDNA neutrality and population equilibrium. The deep coalescence times (exceeding 50,000 yr) of sequences associated with the two most frequent restriction haplotypes confirm that the Niokolo Mandenka population has not passed through a recent bottleneck and thatgene flow is maintained among West African populations despite ethnicdifferences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 21:13:12