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Titolo:
COMPARISON OF 2ND-MESSENGER RESPONSES TO MUSCARINIC RECEPTOR STIMULATION IN M1-TRANSFECTED A9-L-CELLS
Autore:
BAUMGOLD J; DYER K; FALCONE JF; BYMASTER FP;
Indirizzi:
RECEPTOR BIOL INC,5202 WESTLAND BLVD BALTIMORE MD 21227 GEORGE WASHINGTON UNIV,MED CTR,DEPT RADIOL WASHINGTON DC 20037 GEORGE WASHINGTON UNIV,MED CTR,DEPT PHARMACOL WASHINGTON DC 20037 ELI LILLY & CO,ELI LILLY RES LABS INDIANAPOLIS IN 46285
Titolo Testata:
Cellular signalling
fascicolo: 1, volume: 7, anno: 1995,
pagine: 39 - 43
SICI:
0898-6568(1995)7:1<39:CO2RTM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
2ND MESSENGERS; HYDROLYSIS; SUBTYPES; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J. Baumgold et al., "COMPARISON OF 2ND-MESSENGER RESPONSES TO MUSCARINIC RECEPTOR STIMULATION IN M1-TRANSFECTED A9-L-CELLS", Cellular signalling, 7(1), 1995, pp. 39-43

Abstract

A9 L cells stable transfected with m1 muscarinic receptors were stimulated with the full agonist carbachol and with the partial agonist pilocarpine. The EC(50) values and maximal activation from PI hydrolysis,calcium mobilization, membrane hyperpolarization, cell proliferation and arachidonic acid release were compared. Pilocarpine was approximately half as effective in eliciting PI hydrolysis, calcium mobilizationand arachidonic acid release, but was almost as effective as carbachol in the other assays. These findings suggest that the intracellular signals leading to receptor-mediated cell proliferation and to membranehyperpolarization are amplified, and that therefore these assays are not suitable for determining whether a compound is a partial agonist.

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Documento generato il 09/04/20 alle ore 00:31:14