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Titolo:
DO TRANS-FATTY-ACIDS IMPAIR LINOLEIC-ACID METABOLISM IN CHILDREN
Autore:
DECSI T; KOLETZKO B;
Indirizzi:
UNIV MUNICH,KINDERPOLIKLIN,PETTENKOFERSTR 8A D-80336 MUNICH GERMANY
Titolo Testata:
Annals of nutrition & metabolism
fascicolo: 1, volume: 39, anno: 1995,
pagine: 36 - 41
SICI:
0250-6807(1995)39:1<36:DTILMI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATURE HUMAN-MILK; ARACHIDONIC-ACID; RAT-LIVER; BIOSYNTHESIS; GROWTH; DESATURATION; CHOLESTEROL; GERMANY; TISSUES; LIPIDS;
Keywords:
PEDIATRIC NUTRITION; TRANS FATTY ACIDS; PARTIALLY HYDROGENATED FATS; LONG-CHAIN POLYUNSATURATED; FATTY ACIDS; ESSENTIAL FATTY ACIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
T. Decsi e B. Koletzko, "DO TRANS-FATTY-ACIDS IMPAIR LINOLEIC-ACID METABOLISM IN CHILDREN", Annals of nutrition & metabolism, 39(1), 1995, pp. 36-41

Abstract

Trans isomeric fatty acids disturb themetabolism of essential polyunsaturated fatty acids in animals and in premature infants. We assessed whether similar effects may also occur in healthy children. Plasma phospholipid fatty acid composition was analysed in 53 apparently healthychildren aged 1-15 years (mean 7.5 years). Trans fatty acids were found in all samples and contributed 1.78 +/- 0.10% (w/w, mean +/- SEM). There was no relation of the major trans isomer octadecenoic acid and of total trans fatty acids to the precursor essential fatty acid linoleic acid. In contrast, we found significant inverse correlations of trans octadecenoic acid and total trans isomers to the principal n-6 metabolite arachidonic acid as well as to the sum of all n-6 metabolites. Furthermore, there was an inverse correlation of total trans fatty acids to the ratio of arachidonic to linoleic acid, an indirect indicator of linoleic acid conversion. These findings are compatible with inhibition of arachidonic acid biosynthesis by trans fatty acids. Since the availability of long-chain polyunsaturated fatty acids, including arachidonic acid, is of essential importance for tissue growth and development, these findings question the safety of high dietary trans fattyacid intakes in childhood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 03:59:51