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Titolo:
SAFETY OF INTRAPLEURALLY ADMINISTERED RECOMBINANT ADENOVIRUS CARRYINGHERPES-SIMPLEX THYMIDINE KINASE DNA FOLLOWED BY GANCICLOVIR THERAPY IN NONHUMAN-PRIMATES
Autore:
KUCHARCZUK JC; RAPER S; ELSHAMI AA; AMIN KM; STERMAN DH; WHEELDON EB; WILSON JM; LITZKY LA; KAISER LR; ALBELDA SM;
Indirizzi:
UNIV PENN,MED CTR,THORAC ONCOL RES LAB,810 MALONEY BLDG,3400 SPRUCE ST PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT SURG,THORAC SURG SECT PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT MED,DIV PULM & CRIT CARE PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT PATHOL PHILADELPHIA PA 19104 UNIV PENN,MED CTR,INST HUMAN GENE THERAPY PHILADELPHIA PA 19104
Titolo Testata:
Human gene therapy
fascicolo: 18, volume: 7, anno: 1996,
pagine: 2225 - 2233
SICI:
1043-0342(1996)7:18<2225:SOIARA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED GENE-THERAPY; IN-VITRO; CANCER; MESOTHELIOMA; MODEL; VIVO; CDNA; RATS; LUNG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Kucharczuk et al., "SAFETY OF INTRAPLEURALLY ADMINISTERED RECOMBINANT ADENOVIRUS CARRYINGHERPES-SIMPLEX THYMIDINE KINASE DNA FOLLOWED BY GANCICLOVIR THERAPY IN NONHUMAN-PRIMATES", Human gene therapy, 7(18), 1996, pp. 2225-2233

Abstract

Preclinical safety and toxicity studies of intrapleural administration of recombinant adenovirus carrying the herpes simplex thymidine kinase gene (H5.010RSVtk) were performed, Previously reported experimentalevidence has demonstrated the efficacy of this approach in animal models of a localized thoracic cancer, malignant mesothelioma, H5.010RSVtk was delivered at high dose (10(12) pfu) into the pleural cavity of three nonhuman primates followed by systemic administration of ganciclovir, No clinical toxicity was noted, Although an inflammatory reactionobservable by microscopy was noted in the serosal spaces of the chestcavity, these changes were reversible and were not associated with radiographic sequelae, Extrathoracic viral dissemination was minimal anddetectable only by sensitive polymerase chain reaction techniques, This low level of viral dissemination was not associated with detectableclinical, biochemical, or pathologic abnormalities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:46:27