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Titolo:
EXOSURF RESCUE SURFACTANT IMPROVES HIGH VENTILATION-PERFUSION MISMATCH IN RESPIRATORY-DISTRESS SYNDROME
Autore:
BILLMAN D; NICKS J; SCHUMACHER R;
Indirizzi:
MED COLL WISCONSIN,MED CTR,DEPT PEDIAT,NEONATAL SECT,BOX 174,8700 W WISCONSIN AVE MILWAUKEE WI 53226 UNIV MICHIGAN,MED CTR,DEPT PEDIAT RESP THERAPY ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT PEDIAT,NEWBORN SERV SECT ANN ARBOR MI 48109
Titolo Testata:
Pediatric pulmonology
fascicolo: 5, volume: 18, anno: 1994,
pagine: 279 - 283
SICI:
8755-6863(1994)18:5<279:ERSIHV>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYALINE-MEMBRANE DISEASE; MEAN AIRWAY PRESSURE; SYNTHETIC SURFACTANT; REPLACEMENT THERAPY; PRETERM INFANTS; DUCTUS-ARTERIOSUS; CARBON-DIOXIDE; LUNG-MECHANICS; CAPNOGRAPHY; VOLUME;
Keywords:
ARTERIAL ALVEOLAR CO2 TENSION; ALVEOLAR-ARTERIAL O-2 TENSION; ALVEOLAR ARTERIAL O-2 TENSION; OXYGENATION INDEX; MEAN AIRWAY PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
D. Billman et al., "EXOSURF RESCUE SURFACTANT IMPROVES HIGH VENTILATION-PERFUSION MISMATCH IN RESPIRATORY-DISTRESS SYNDROME", Pediatric pulmonology, 18(5), 1994, pp. 279-283

Abstract

Objective: To assess ventilation/perfusion (V-A/Q) mismatch of the high type, following rescue surfactant therapy for respiratory distress syndrome. Hypothesis: Surfactant therapy reduces such mismatch. Design: Randomized, doubte-blind, placebo-controlled study, assessing V-A/Q with the arterial-alveolar difference of CO2 tension (P((a-A)CO2)). This difference was determined with capnometry and arterial blood gases,using the equation: P((a-A)CO2) equals arterial CO2 minus alveolar CO2 partial pressure. Setting: A level III nursery. Patients: Ten intubated infants with respiratory distress syndrome. Intervention: Infants were randomized to each receive two doses of surfactant or two doses of air placebo. Results: P((a-A)CO2) improved after surfactant and worsened after placebo (P = 0.0021), comparing slopes of 12-hr regression lines. A similar pattern occurred with oxygenation. These changes in P((a-A)CO2) and in oxygenation were minimally correlated within the surfactant group. Conclusion: Exosurf rescue surfactant reduced V-A/Q mismatch of the high type, over several hours. (C) 1994 Wiley-Liss.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:06:23