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Titolo:
A GENETIC-LOCUS OF ENTEROCYTE EFFACEMENT CONSERVED AMONG DIVERSE ENTEROBACTERIAL PATHOGENS
Autore:
MCDANIEL TK; JARVIS KG; DONNENBERG MS; KAPER JB;
Indirizzi:
UNIV MARYLAND,SCH MED,DEPT MED,CTR VACCINE DEV,10 S PINE ST BALTIMOREMD 21201 UNIV MARYLAND,SCH MED,DEPT MED,CTR VACCINE DEV BALTIMORE MD 21201 UNIV MARYLAND,SCH MED,GRAD PROGRAM MOLEC & CELL BIOL BALTIMORE MD 21201 UNIV MARYLAND,SCH MED,DEPT VET AFFAIRS MED CTR,MED SERV BALTIMORE MD 21201 UNIV MARYLAND,SCH MED,DEPT MED,DIV INFECT DIS BALTIMORE MD 21201
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 5, volume: 92, anno: 1995,
pagine: 1664 - 1668
SICI:
0027-8424(1995)92:5<1664:AGOEEC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENTEROPATHOGENIC ESCHERICHIA-COLI; CITROBACTER-FREUNDII BIOTYPE; MURINE COLONIC HYPERPLASIA; HEMOLYTIC UREMIC SYNDROME; CAUSE HEMORRHAGIC COLITIS; TISSUE-CULTURE CELLS; TRANSFER-RNA GENE; EAE GENE; EPITHELIAL-CELLS; HEP-2 CELLS;
Keywords:
BACTERIAL PATHOGENESIS; EPITHELIAL CELLS; ATTACHING AND EFFACING LESIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
T.K. Mcdaniel et al., "A GENETIC-LOCUS OF ENTEROCYTE EFFACEMENT CONSERVED AMONG DIVERSE ENTEROBACTERIAL PATHOGENS", Proceedings of the National Academy of Sciences of the United Statesof America, 92(5), 1995, pp. 1664-1668

Abstract

Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli 0157:H7 are intestinal pathogens that profoundly damage the microvilli and subapical cytoskeleton of epithelial cells. Here we report finding in EPEC a 35-kbp locus containing several regions implicated in formation of these lesions. DNA probes throughout this locus hybridize to E. coli O157:H7 and other pathogens of three genera that cause similar lesions but do not hybridize to avirulent members of the same species. The EPEC locus and a different virulence locus of uropathogenic E.coli insert into the E. coli chromosome at the identical site and share highly similar sequences near the point of insertion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:49:33