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Titolo:
CONTROLLED-STUDY OF HUMAN HERPESVIRUS-6 DETECTION IN ACQUIRED IMMUNODEFICIENCY SYNDROME-ASSOCIATED NON-HODGKINS-LYMPHOMA
Autore:
FILLET AM; RAPHAEL M; VISSE B; AUDOUIN J; POIREL L; AGUT H;
Indirizzi:
HOP LA PITIE SALPETRIERE,CERVI,VIROL LAB,83 BLD HOP F-75651 PARIS 13 FRANCE HOP LA PITIE SALPETRIERE,BACTERIOL VIROL LAB,CNRS,EP 57 PARIS FRANCE HOP LA PITIE SALPETRIERE,DEPT HEMATOL,CELL ECOL LAB PARIS FRANCE HOP HOTEL DIEU,DEPT PATHOL PARIS FRANCE
Titolo Testata:
Journal of medical virology
fascicolo: 1, volume: 45, anno: 1995,
pagine: 106 - 112
SICI:
0146-6615(1995)45:1<106:COHHDI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; B-LYMPHOTROPIC VIRUS; EPSTEIN-BARR-VIRUS; INSITU HYBRIDIZATION; DNA AMPLIFICATION; CYTOMEGALO-VIRUS; LYMPHOCYTES-T; INFECTION; AIDS; DIAGNOSIS;
Keywords:
PCR; LYMPHOTROPIC HERPESVIRUS; LYMPHOPROLIFERATIVE DISEASES; HHV-6 VARIANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Fillet et al., "CONTROLLED-STUDY OF HUMAN HERPESVIRUS-6 DETECTION IN ACQUIRED IMMUNODEFICIENCY SYNDROME-ASSOCIATED NON-HODGKINS-LYMPHOMA", Journal of medical virology, 45(1), 1995, pp. 106-112

Abstract

Human herpesvirus 6 (HHV-6) is a recently identified lymphotropic herpesvirus, which has been isolated from patients with acquired immunodeficiency syndrome (AIDS) or lymphoproliferative diseases. Two variantsA and B of HHV-6 have been described, variant 6 being more common in children with exanthema subitum. HHV-6 infection was studied in cases of AIDS-associated non-Hodgkin's lymphoma (NHL), and in three control populations in order to evaluate the possible etiological role of HHV-6 in this lymphoproliferative disease. Tumor specimens from various organs were obtained from 27 patients with AIDS-associated NHL and 20 human immunodeficiency virus (HIV)-seronegative patients with NHL. Lymphnode specimens were obtained from four HIV-seropositive and nine HIV-seronegative patients with lymph node follicular hyperplasia. A specific polymerase chain reaction (PCR) was used to detect HHV-6 DNA. Subsequently HHV-6 variant was identified by using variant-specific PCR. Human cytomegalovirus (CMV) infection was detected in parallel by means of specific PCR. HHV-6 DNA was detected in 12 of 27 tumor tissues (44%), including 8 of 15 lymph node specimens (53%) from patients with AIDS-associated NH L. The corresponding values in HIV-seronegative patients with NHL were 35% (7/20) and 36% (5/14), respectively. Lymph node specimens were positive for HHV-6 in two of four (50%) HIV-seropositiveand five of nine (55%) HIV-seronegative patients with follicular hyperplasia. Variant A was detected in two cases of AIDS-associated NHL, variant B in one case, and both variants in six cases. The distributionof HHV-6 variants exhibited a similar pattern in the three control groups. CMV was only detected in 3 of 27 tumor tissues (11%) from patients with AIDS-associated NHL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:13:35