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Titolo:
DEVELOPMENTAL-CHANGES IN RESPONSE TO ENDOTHELINS AND RECEPTOR SUBTYPES OF ISOLATED RAT DUODENUM
Autore:
IRIE K; UCHIDA Y; FUJII E; MURAKI T;
Indirizzi:
TOKYO WOMENS MED COLL,DEPT PHARMACOL,SHINJUKU KU,8-1 KAWADA CHO TOKYO162 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 275, anno: 1995,
pagine: 45 - 51
SICI:
0014-2999(1995)275:1<45:DIRTEA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG ILEUM; VASCULAR SMOOTH-MUSCLE; MESSENGER-RNA; HORMONE TRH; NA+ IONS; CLONING; CALCIUM; POTENT; RELAXATION; CELLS;
Keywords:
ENDOTHELIN; ENDOTHELIN RECEPTOR SUBTYPE; IRL 1620; FR139317; RES-701-1; DUODENUM; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
K. Irie et al., "DEVELOPMENTAL-CHANGES IN RESPONSE TO ENDOTHELINS AND RECEPTOR SUBTYPES OF ISOLATED RAT DUODENUM", European journal of pharmacology, 275(1), 1995, pp. 45-51

Abstract

The response of isolated duodenum to endothelin-1, -3 and IRL 1620 (Suc-[Glu(9),Ala(11,15)]endothelin-1 (8-21)), a selective endothelin ET(B) receptor agonist, was studied in both neonatal (1-week-old) and adult rats by recording mechanical activity isotonically. Endothelin-1, -3 and IRL 1620 (1-100 nM) elicited sustained contraction of neonatal duodenum, in a concentration-dependent manner, with a potency order of endothelin-1 = endothelin-3 > IRL 1620. The response to endothelin-1 and -3 (10-1000 nM) of adult duodenum was biphasic, i.e., transient relaxation followed by contraction, with a potency order of endothelin-1 > endothelin-3. The contractile response to endothelin-1 of adult but not neonatal duodenum was significantly antagonized by pretreatment with FR139317 (1 mu M), an endothelin ET(A) receptor antagonist. An endothelin ET(B) receptor antagonist, RES-701-1 (3 mu M), weakly antagonized the IRL 1620-induced contraction of neonatal duodenum. However, RES-701-1 (10 mu M) did not affect the response to endothelin-1 of eitheradult or neonatal duodenum. These results indicate that the duodenal response to endothelins changes from a sustained contraction in neonates to a biphasic response in adults. The contractile response to endothelins of neonatal duodenum is suggested to be mediated through endothelin ET(B) receptors or possibly RES-701-1-resistant ET(B) receptor subtypes and contraction of adult duodenum through endothelin ET(A) receptors. The mechanism of the endothelin-induced response of duodenum was also studied.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:46:46