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Titolo:
SELENIUM CONCENTRATIONS IN BRAIN AFTER EXPOSURE TO METHYLMERCURY - RELATIONS BETWEEN THE INORGANIC MERCURY FRACTION AND SELENIUM
Autore:
BJORKMAN L; MOTTET K; NYLANDER M; VAHTER M; LIND B; FRIBERG L;
Indirizzi:
KAROLINSKA INST,INST ENVIRONM MED,POB 210 S-17177 STOCKHOLM SWEDEN UNIV WASHINGTON,SCH MED,DEPT PATHOL & ENVIRONM HLTH SEATTLE WA 98195 KAROLINSKA INST,CLIN RES CTR,APPL BIOCHEM UNIT S-14157 HUDDINGE SWEDEN UNIV TEXAS,INST BIOMED RES AUSTIN TX 78712
Titolo Testata:
Archives of toxicology
fascicolo: 4, volume: 69, anno: 1995,
pagine: 228 - 234
SICI:
0340-5761(1995)69:4<228:SCIBAE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUES; RATS;
Keywords:
BRAIN; SELENIUM; INORGANIC MERCURY; METHYLMERCURY; MONKEYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
L. Bjorkman et al., "SELENIUM CONCENTRATIONS IN BRAIN AFTER EXPOSURE TO METHYLMERCURY - RELATIONS BETWEEN THE INORGANIC MERCURY FRACTION AND SELENIUM", Archives of toxicology, 69(4), 1995, pp. 228-234

Abstract

Three groups of female monkeys (Macaca fascicularis) were exposed to methylmercury (MeHg, p.o. 50 mu g HE/kg body wt per day) for 6, 12, or18 months, One group was exposed to MeHg for 12 months and kept unexposed for 6 months before sacrifice. Another group of three monkeys wasexposed to HgCl2 i.v. for 3 months. Total and inorganic mercury concentrations in occipital pole and thalamus were determined by cold vaporatomic absorption spectroscopy. Selenium concentrations were analyzedby hydride generation atomic absorption spectroscopy, The results indicated an association between concentrations of inorganic mercury and selenium in both occipital pole and thalamus in the MeHg-exposed animals, A linear regression model using concentrations of inorganic mercury (nmol/g wet wt) as independent variable, and selenium concentrations(nmol/g wet wt) as the dependent variable showed significant correlations between the variables in both occipital pole and thalamus (r = 0.85 and r = 0.91, P < 0.0001). The intercept of the regression line wasslightly lower (about 2 nmol Se/g wet wt) than the selenium concentrations found in control monkeys (about 3 nmol Se/g wet wt). There was atendency to a ''hockey stick''-shaped relationship between concentrations of selenium and inorganic mercury in the thalamus of monkeys withongoing exposure to MeHg. An important role for selenium in the retention of mercury in brain is indicated.

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Documento generato il 03/12/20 alle ore 15:23:49