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Titolo:
NEUTRALIZING ANTI-P21(RAS) FABS SUPPRESS RAT SYMPATHETIC NEURON SURVIVAL INDUCED BY NGF, LIF, CNTF AND CAMP
Autore:
NOBES CD; TOLKOVSKY AM;
Indirizzi:
UNIV CAMBRIDGE,DEPT BIOCHEM,TENNIS COURT RD CAMBRIDGE CB2 1QW ENGLAND UNIV CAMBRIDGE,DEPT BIOCHEM CAMBRIDGE CB2 1QW ENGLAND UNIV OXFORD,DEPT HUMAN ANAT OXFORD OX1 3QX ENGLAND
Titolo Testata:
European journal of neuroscience
fascicolo: 2, volume: 7, anno: 1995,
pagine: 344 - 350
SICI:
0953-816X(1995)7:2<344:NAFSRS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; CILIARY NEUROTROPHIC FACTOR; LEUKEMIA INHIBITORY FACTOR; DEPENDENT PROTEIN-KINASE; CYCLIC-AMP; TYROSINE PHOSPHORYLATION; DIFFERENTIATION FACTOR; NUCLEOTIDE EXCHANGE; NEURITE OUTGROWTH; SENSORY NEURONS;
Keywords:
APOPTOSIS; HISTONES; RAT SUPERIOR CERVICAL GANGLION; TYROSINE PHOSPHORYLATION; PKA;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
C.D. Nobes e A.M. Tolkovsky, "NEUTRALIZING ANTI-P21(RAS) FABS SUPPRESS RAT SYMPATHETIC NEURON SURVIVAL INDUCED BY NGF, LIF, CNTF AND CAMP", European journal of neuroscience, 7(2), 1995, pp. 344-350

Abstract

In purified cultures of newly isolated rat sympathetic neurons platedon laminin, apoptosis is suppressed by the cytokines leukaemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF), by the permeant cAMP analogue 8-(4-chloropheny]thio)cAMP, and by nerve growth factor. Whilst nerve growth factor, 8-(4-chlorophenylthio)cAMP and LIF/CNTF initiate survival by using different kinases, in each case survival is inhibited by a Fab fragment of Y13-259, a neutralizing antibody to p21ras proteins, but not by rat IgG Fab. The inhibitory effect of Y13-259 could be partially attenuated by cotrituration of the Fab with T'24(inactive)ras. Thus, prevention of apoptosis in rat sympathetic neurons by several different survival factors appears to be critically dependent on p21ras protein activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 17:05:56