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Titolo:
REDUCTION OF MYOCARDIAL ECG-MONITORED ISC HEMIA DURING CORONARY-ARTERY BYPASS-GRAFTING BY DILTIAZEM
Autore:
LISCHKE V; PROBST S; BEHNE M; DIETERICH HA;
Indirizzi:
UNIV FRANKFURT KLINIKUM,ZENTRUM ANAESTHESIOL & WIEDERBELEBUNG,THEODORSTERN KAI 7 D-60596 FRANKFURT GERMANY GEORGE TOWN UNIV,SCH MED,DEPT MED WASHINGTON DC 00000 GEORGE TOWN UNIV,SCH MED,DEPT PHARMACOL WASHINGTON DC 00000
Titolo Testata:
Anasthesist
fascicolo: 2, volume: 44, anno: 1995,
pagine: 92 - 100
SICI:
0003-2417(1995)44:2<92:ROMEIH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
GER
Soggetto:
INTRAVENOUS NITROGLYCERIN; NONCARDIAC SURGERY; RANDOMIZED TRIAL; ISCHEMIA; INFARCTION; PROTECTION; PREVENTION; ANESTHESIA;
Keywords:
MYOCARDIAL ISCHEMIA; ST-SEGMENT; AORTOCORONARY BYPASS GRAFTING; DILTIAZEM; NITROGLYCERIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
V. Lischke et al., "REDUCTION OF MYOCARDIAL ECG-MONITORED ISC HEMIA DURING CORONARY-ARTERY BYPASS-GRAFTING BY DILTIAZEM", Anasthesist, 44(2), 1995, pp. 92-100

Abstract

The incidence of postoperative myocardial infarction (MI) is proportional to the incidence of myocardial ischaemic episodes. Therefore, theprevention of such episodes is of great clinical importance. Methods. In 90 patients undergoing coronary artery bypass grafting (CABG), perioperative i.v. treatment with either nitroglycerin (NTG), diltiazem (DIL), or the combination of DIL/NTG was used until arrival in the intensive care unit. Myocardial ischaemic episodes were monitored with an automatic ECG-ST-trend analyser (Marquette 7010). Results. Significantly less ischaemic episodes were seen in the DIL group (6.7%) compared to the NTG group (13.2%) or DIL/NTG group (13.5%). Furthermore, significantly less ischaemic episodes were associated with relevant haemodynamic alterations in the DIL group (58.1%) compared to the NTG (89.1%) or DIL/NTG group (80.0%). Increases in heart rate were markedly reduced in the DIL group. Discussion. DIL results in marked haemodynamic stabilisation during CABG, especially in the period immediately after extra-corporeal circulation. This might serve as an explanation for the significant reduction in ischaemic episodes in the DIL group compared to the other two groups. Therefore, perioperative prevention of myocardial ischaemia with the calcium antagonist DIL seems to be favourable in patients during CABG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 18:52:29