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Titolo:
THE MHC-ENCODED TAP1 LMP2 BIDIRECTIONAL PROMOTER IS DOWN-REGULATED INHIGHLY ONCOGENIC ADENOVIRUS-TYPE-12 TRANSFORMED-CELLS/
Autore:
PROFFITT JA; BLAIR GE;
Indirizzi:
UNIV LEEDS,DEPT BIOCHEM & MOL BIOL LEEDS LS2 9JT W YORKSHIRE ENGLAND UNIV LEEDS,DEPT BIOCHEM & MOL BIOL LEEDS LS2 9JT W YORKSHIRE ENGLAND
Titolo Testata:
FEBS letters
fascicolo: 2, volume: 400, anno: 1997,
pagine: 141 - 144
SICI:
0014-5793(1997)400:2<141:TMTLBP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I MOLECULES; RAT-CELLS; PEPTIDE TRANSPORTER; T-CELLS; EXPRESSION; ANTIGENS; GENES; TUMORIGENICITY; IDENTIFICATION; PROTEASOMES;
Keywords:
GENE EXPRESSION; NUCLEOTIDE SEQUENCE; VIRAL SUPPRESSION OF THE MHC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Proffitt e G.E. Blair, "THE MHC-ENCODED TAP1 LMP2 BIDIRECTIONAL PROMOTER IS DOWN-REGULATED INHIGHLY ONCOGENIC ADENOVIRUS-TYPE-12 TRANSFORMED-CELLS/", FEBS letters, 400(2), 1997, pp. 141-144

Abstract

Cells transformed by human adenovirus 12 (Ad12) exhibit extremely lowsurface levels of MHC class I molecules and contain reduced levels ofclass I heavy chain mRNAs. We report that levels of MHC-encoded TAP1 and LMP2 mRNAs are also down-regulated in Ad12-transformed rat cells, and that transcription of rat TAP1 and LMP2 transcripts is directed from a 564 bp intergenic region which is significantly less active in Ad12-transformed cells compared to those transformed with Ad5. Our results suggest that, in common with MHC class I gene expression, TAP1 and LMP2 gene expression is reduced mainly at the level of transcription in Ad12-transformed cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 23:06:18