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Titolo:
CHARACTERIZATION OF THE INTERACTION BETWEEN GUANYL NUCLEOTIDES AND AMPA RECEPTORS IN RAT-BRAIN
Autore:
DEV KK; ROBERTS PJ; HENLEY JM;
Indirizzi:
UNIV BRISTOL,SCH MED SCI,DEPT ANAT,UNIV WALK BRISTOL BS8 1TD AVON ENGLAND UNIV BRISTOL,SCH MED SCI,DEPT ANAT BRISTOL BS8 1TD AVON ENGLAND UNIV BRISTOL,SCH MED,DEPT PHARMACOL BRISTOL BS8 1TD AVON ENGLAND
Titolo Testata:
Neuropharmacology
fascicolo: 11, volume: 35, anno: 1996,
pagine: 1583 - 1593
SICI:
0028-3908(1996)35:11<1583:COTIBG>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUTATIVE GLUTAMATE RECEPTOR; KAINATE-BINDING SUBUNIT; METHYL-D-ASPARTATE; GUANINE-NUCLEOTIDES; GOLDFISH BRAIN; CORTICAL MEMBRANES; G-PROTEINS; H-3 AMPA; ACID; ANTAGONIST;
Keywords:
FLUOROWILLARDIINE; AMPA; CNQX; GTP; GUANYL NUCLEOTIDES; AUTORADIOGRAPHY; RAT CORTEX; GLUTAMATE RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
K.K. Dev et al., "CHARACTERIZATION OF THE INTERACTION BETWEEN GUANYL NUCLEOTIDES AND AMPA RECEPTORS IN RAT-BRAIN", Neuropharmacology, 35(11), 1996, pp. 1583-1593

Abstract

Guanyl nucleotides inhibit the binding of the AMPA receptor agonists [H-3]fluorowillardiine and [H-3]AMPA and the competitive antagonist [H-3]CNQX to rat brain cerebrocortical membranes. The rank order of inhibition for each of the radioligands tested was GTP > GDP > GMP. The nucleotides CTP and ATP showed no effect. GTP inhibition was unaffected by the presence or absence of NaCl and MgCl2. Pre-treatment of the membranes with GTP, and its removal before addition of radioligand, did not inhibit binding. Quantitative autoradiography demonstrated that GTPinhibition occurred throughout the brain. These results are consistent with guanyl nucleotides acting at an extracellular site present on all AMPA receptor subunits, occupation of which inhibits agonist and antagonist binding. Copyright (C) 1996 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:24:39