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Titolo:
DOPAMINE-RECEPTORS AND BRAIN-FUNCTION
Autore:
JABER M; ROBINSON SW; MISSALE C; CARON MG;
Indirizzi:
DUKE UNIV,MED CTR,HOWARD HUGHES MED INST LABS,DEPT CELL BIOL DURHAM NC 27710 DUKE UNIV,MED CTR,HOWARD HUGHES MED INST LABS,DEPT CELL BIOL DURHAM NC 27710 DUKE UNIV,MED CTR,HOWARD HUGHES MED INST LABS,DEPT MED DURHAM NC 27710
Titolo Testata:
Neuropharmacology
fascicolo: 11, volume: 35, anno: 1996,
pagine: 1503 - 1519
SICI:
0028-3908(1996)35:11<1503:DAB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA LEVELS; ANTERIOR-PITUITARY-CELLS; RAT LACTOTROPH CELLS; HAMSTER OVARY CELLS; PROTEIN-KINASE-C; QUANTITATIVE INSITU HYBRIDIZATION; SENSITIVE ADENYLATE-CYCLASE; NUCLEOTIDE-BINDING PROTEINS; THRESHOLD CALCIUM CURRENTS; ARACHIDONIC-ACID RELEASE;
Keywords:
DOPAMINE RECEPTORS; BASAL GANGLIA; PITUITARY; SIGNAL TRANSDUCTION; GENE EXPRESSION; SCHIZOPHRENIA; NEUROLEPTICS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
189
Recensione:
Indirizzi per estratti:
Citazione:
M. Jaber et al., "DOPAMINE-RECEPTORS AND BRAIN-FUNCTION", Neuropharmacology, 35(11), 1996, pp. 1503-1519

Abstract

In the central nervous system (CNS), dopamine is involved in the control of locomotion, cognition, affect and neuroendocrine secretion. These actions of dopamine are mediated by five different receptor subtypes, which are members of the large G-protein coupled receptor superfamily. The dopamine receptor subtypes are divided into two major subclasses: the D-1-like and D-2-like receptors, which typically couple to G(s) and G(j) mediated transduction systems. In the CNS, the various receptor subtypes display specific anatomical distributions, with D-1-likereceptors being mainly post-synaptic and D-2-like receptors being both pre- and post-synaptic. D-1 and D-2 dopamine receptors, the most abundant subtypes in the CNS, appear to be expressed largely in distinct neurons. Substance P and dynorphin, which are expressed in D-1 receptor-containing neurons, as well as pre-proenkephalin in D-2 receptor-containing neurons, have been used as monitors of dopaminergic activity in the CNS. Expression of immediate early genes, in particular fos, hasalso been found to correlate with dopaminergic transmission. Dopaminereleased from the hypothalamus controls the synthesis and secretion of prolactin from the anterior pituitary via D-2 dopamine receptors. Asyet, none of the dopamine receptor subtypes have been associated withthe etiology of psychotic disorders, such as schizophrenia. However, the recent characterization of D-3 and D-4 receptors which are, interestingly, expressed in areas of the CNS mediating cognition and affect or showing increased affinity for certain neuroleptics, have renewed the interest and hope of finding effective neuroleptics devoid of side effects. Finally, the recent production of genetically-derived animalslacking several of these receptor genes should help elucidate which specific physiological paradigms the receptors mediate. Copyright (C) 1996 Elsevier Science Ltd.

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Documento generato il 17/01/20 alle ore 20:11:11