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Titolo:
A SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY SCAN STUDY OF STRIATAL DOPAMINE D-2 RECEPTOR-BINDING WITH I-123 EPIDEPRIDE IN PATIENTS WITH SCHIZOPHRENIA AND CONTROLS
Autore:
TIBBO P; SILVERSTONE PH; MCEWAN AJB; SCOTT J; JOSHUA A; GOLBERG K;
Indirizzi:
UNIV ALBERTA HOSP,DEPT PSYCHIAT EDMONTON AB T6G 2B7 CANADA UNIV ALBERTA,DEPT PSYCHIAT EDMONTON AB CANADA UNIV ALBERTA,DEPT RADIOL EDMONTON AB CANADA CROSS CANC INST EDMONTON AB T6G 1Z2 CANADA EDMONTON RADIOPHARMACEUT CTR EDMONTON AB CANADA
Titolo Testata:
Journal of psychiatry & neuroscience
fascicolo: 1, volume: 22, anno: 1997,
pagine: 39 - 45
SICI:
1180-4882(1997)22:1<39:ASECSS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BRAIN; I-125 EPIDEPRIDE; BASAL GANGLIA; SPECT; INVIVO; IBZM; PET; OCCUPANCY; VISUALIZATION; RADIOLIGANDS;
Keywords:
I-123 EPIDEPRIDE; D-2 RECEPTOR; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; AMPHETAMINE; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
P. Tibbo et al., "A SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY SCAN STUDY OF STRIATAL DOPAMINE D-2 RECEPTOR-BINDING WITH I-123 EPIDEPRIDE IN PATIENTS WITH SCHIZOPHRENIA AND CONTROLS", Journal of psychiatry & neuroscience, 22(1), 1997, pp. 39-45

Abstract

The usefulness of I-123-epidepride as a single photon emission computed tomography (SPECT) scan D-2 receptor ligand was examined in vivo in13 medicated patients with schizophrenia and age- and sex-matched normal controls. To establish the effect of endogenous dopamine on I-123-epidepride binding, 4 of the 13 controls also received 20 mg D-amphetamine. The results showed that I-123-epidepride had high specific binding to the striatum in both patients with schizophrenia and normal controls. There was a trend for the total striatal binding of medicated patients with schizophrenia, as measured by total basal ganglia:frontal cortex (TBG:FC) ratios, to be less than the binding of controls (P = 0.053), This trend confirms previous work showing that antipsychotic medication decreases the number of D-2 receptors available for binding to the radioligand, Interestingly, there was also a significant relationship between I-123-epidepride binding ratios and global functioning scales (Global Assessment of Functioning scale [GAF]) for schizophrenia(r = 0.56, P = 0.045), although there was no such relationship with the Brief Psychiatric Rating Scale (BPRS), In addition, our results showed that amphetamine-induced dopamine release did not alter I-123-epidepride binding, confirming the high specific binding of I-123-epidepride to the D-2 receptor, We conclude that I-123-epidepride appears to be a very useful SPECT ligand for imaging the D-2 receptor.

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Documento generato il 20/11/19 alle ore 03:33:38