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Titolo:
THE RYANODINE RECEPTOR CALCIUM-CHANNEL GENES ARE WIDELY AND DIFFERENTIALLY EXPRESSED IN MURINE BRAIN AND PERIPHERAL-TISSUES
Autore:
GIANNINI G; CONTI A; MAMMARELLA S; SCROBOGNA M; SORRENTINO V;
Indirizzi:
IST SCI SAN RAFFAELE,DIBIT,VIA OLGETTINA 58 I-20132 MILAN ITALY IST SCI SAN RAFFAELE,DIBIT I-20132 MILAN ITALY EUROPEAN MOLEC BIOL LAB HEIDELBERG GERMANY UNIV SIENA,SCH MED,INST HISTOL I-53100 SIENA ITALY
Titolo Testata:
The Journal of cell biology
fascicolo: 5, volume: 128, anno: 1995,
pagine: 893 - 904
SICI:
0021-9525(1995)128:5<893:TRRCGA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; MUSCLE SARCOPLASMIC-RETICULUM; CA2+ RELEASE CHANNELS; CYCLIC ADP-RIBOSE; SEA-URCHIN EGGS; SKELETAL-MUSCLE; ENDOPLASMIC-RETICULUM; MOLECULAR-CLONING; CARDIAC-MUSCLE; BINDING SITES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
G. Giannini et al., "THE RYANODINE RECEPTOR CALCIUM-CHANNEL GENES ARE WIDELY AND DIFFERENTIALLY EXPRESSED IN MURINE BRAIN AND PERIPHERAL-TISSUES", The Journal of cell biology, 128(5), 1995, pp. 893-904

Abstract

Ryanodine receptors (RyRs) are intracellular calcium release channelsthat participate in controlling cytosolic calcium levels. At variancewith the probably ubiquitous inositol 1,4,5-trisphosphate-operated calcium channels (1,4,5-trisphosphate receptors), RyRs have been mainly regarded as the calcium release channels controlling skeletal and cardiac muscle contraction. Increasing evidence has recently suggested that RyRs may be more widely expressed, but this has never been extensively examined. Therefore, we cloned three cDNAs corresponding to murine RyR homologues to carry a comprehensive analysis of their expression in murine tissues. Here, we report that the three genes are expressed in almost all tissues analyzed, where tissue-specific patterns of expression were observed. In the uterus and vas deferens, expression of RyR3 was localized to the smooth muscle component of these organs. In thetestis, expression of RyR1 and RyR3 was detected in germ cells. RyR mRNAs were also detected in in vitro-cultured cell lines. RyR1, RyR2, and RyR3 mRNA were detected in the cerebrum and in the cerebellum. In situ analysis revealed a cell type-specific pattern of expression in the different regions of the central nervous system. The differential expression of the three ryanodine receptor genes in the central nervous system was also confirmed using specific antibodies against the respective proteins. This widespread pattern of expression suggests that RyRs may participate in the regulation of intracellular calcium homeostasis in a range of cells wider than previously recognized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:47:08