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Titolo:
CONTRACTILE FAILURE IN EARLY MYOCARDIAL-ISCHEMIA - MODELS AND MECHANISMS
Autore:
GASSER RNA; KLEIN W;
Indirizzi:
GRAZ UNIV,MED KLIN,DIV CARDIOL,AUENBRUGGERPL 15 A-8036 GRAZ AUSTRIA
Titolo Testata:
Cardiovascular drugs and therapy
fascicolo: 6, volume: 8, anno: 1994,
pagine: 813 - 822
SICI:
0920-3206(1994)8:6<813:CFIEM->2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR POTASSIUM ACCUMULATION; MAMMALIAN VENTRICULAR MUSCLE; NUCLEAR MAGNETIC-RESONANCE; RABBIT MYOCARDIUM; SKELETAL-MUSCLE; CARDIAC-MUSCLE; K+ CHANNELS; ADENOSINE-TRIPHOSPHATE; ELECTRICAL-ACTIVITY; SIMULATED ISCHEMIA;
Keywords:
POTASSIUM; MYOCARDIUM; ISCHEMIA; K-ATP CHANNEL; CONTRACTILE FAILURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
98
Recensione:
Indirizzi per estratti:
Citazione:
R.N.A. Gasser e W. Klein, "CONTRACTILE FAILURE IN EARLY MYOCARDIAL-ISCHEMIA - MODELS AND MECHANISMS", Cardiovascular drugs and therapy, 8(6), 1994, pp. 813-822

Abstract

In early myocardial ischemia we find a number of salient electrical and ionic alterations. This article reviews action potential shortening, K accumulation, and contractile failure. Enhanced K efflux during early myocardial ischemia has been attributed to a number of mechanisms,including: the inhibition of active K uptake, osmotic changes, effluxof K ions linked to anion extrusion, cation exchange, altered cellular energy levels, in particular, the opening of ATP-dependent K channels, the involvement of other ion channels, a H/K-ion exchanger, and a catecholamine-dependent pathway, The different mechanisms are discussed. Action potential shortening was described as a salient characteristic of myocardial ischemia in 1954 by Trautwein and Dudel, and was attributed to enhanced outward current. Recently it has been shown by several authors that ATP-dependent potassium channels play a key role in this context. Contractile failure in early myocardial ischemia has been explained by shortening of the action potential duration, reduced cytoplasmic free calcium levels, intracellular acidification, and a rise in inorganic phosphate and Rig. In summary, it is concluded that ATP-dependent K channels may be involved in each of these three phenomena.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:06:13