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Titolo:
CHARACTERIZATION OF THE MONONUCLEAR CELL INFILTRATE IN THE GLOMERULUSOF RATS WITH GLOMERULONEPHRITIS
Autore:
RADOUNIKLI A; STAHL RAK; BERGMANN L; SCHOEPPE W; THAISS F;
Indirizzi:
UNIV HAMBURG HOSP,DEPT INTERNAL MED,DIV NEPHROL,MARTINISTR 52 D-20246HAMBURG GERMANY UNIV HAMBURG HOSP,DEPT INTERNAL MED,DIV NEPHROL D-20246 HAMBURG GERMANY UNIV HOSP FRANKFURT,DEPT INTERNAL MED,DIV NEPHROL FRANKFURT GERMANY
Titolo Testata:
Nephrology, dialysis, transplantation
fascicolo: 2, volume: 10, anno: 1995,
pagine: 185 - 190
SICI:
0931-0509(1995)10:2<185:COTMCI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; T-CELLS; INJURY; EXPRESSION; DISEASE; NEPHRITIS; MODEL; LYMPHOCYTES; PROGRESSION; COMPLEMENT;
Keywords:
EXPERIMENTAL GLOMERULONEPHRITIS; LYMPHOCYTES; MONOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A. Radounikli et al., "CHARACTERIZATION OF THE MONONUCLEAR CELL INFILTRATE IN THE GLOMERULUSOF RATS WITH GLOMERULONEPHRITIS", Nephrology, dialysis, transplantation, 10(2), 1995, pp. 185-190

Abstract

Bone marrow-derived inflammatory cells contribute to glomerular damage in experimental glomerulonephritis. The time sequential appearance and the pattern of inflammatory cells in the diseased glomerulus is, however, unclear. We therefore characterized the inflammatory cell infiltrate in a model of unilateral in situ immune complex glomerulonephritis. The cellular infiltrate was specific for the diseased kidney and independent of changes in peripheral blood or spleen. We found an influx of leukocyte common antigen (LCa)-positive and ED1-positive (monocytes/macrophages) cells in isolated glomeruli as early as 24 h after induction of the disease. Lymphocytes of the CD4-, CD8- and CD20-positivephenotypes were present in diseased glomeruli at Day 10. Complement depletion prevented the influx of monocytes/macrophages at 24 h in the glomerulus, which indicates that complement activation is important for the glomerular cell infiltrate at this early time point. The resultsdemonstrate that the inflammatory cell infiltrate is regulated in situ at the glomerular level and not accompanied by similar changes in peripheral blood and spleen cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 19:42:03