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Titolo:
ALLOIMMUNE THROMBOCYTOPENIA - FETAL AND NEONATAL LOSSES RELATED TO CORDOCENTESIS
Autore:
PAIDAS MJ; BERKOWITZ RL; LYNCH L; LOCKWOOD CJ; LAPINSKI R; MCFARLAND JG; BUSSEL JB;
Indirizzi:
TUFTS UNIV,SCH MED,DEPT OBSTET & GYNECOL,DIV MATERNAL FETAL MED,750 WASHINGTON ST,NEMC 360 BOSTON MA 02111 MT SINAI MED CTR,DEPT OBSTET GYNECOL & REPROD SCI NEW YORK NY 10029 BLOOD CTR SE WISCONSIN INC MILWAUKEE WI 53233 CORNELL UNIV,MED CTR,NEW YORK HOSP,DEPT PEDIAT NEW YORK NY 10021
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 2, volume: 172, anno: 1995,
parte:, 1
pagine: 475 - 479
SICI:
0002-9378(1995)172:2<475:AT-FAN>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLANZMANNS THROMBASTHENIA; ALLOANTIGEN; PLATELETS;
Keywords:
ALLOIMMUNE THROMBOCYTOPENIA; CORDOCENTESIS; PLATELET MEMBRANE GLYCOPROTEINS; HUMAN PLATELET ANTIGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Paidas et al., "ALLOIMMUNE THROMBOCYTOPENIA - FETAL AND NEONATAL LOSSES RELATED TO CORDOCENTESIS", American journal of obstetrics and gynecology, 172(2), 1995, pp. 475-479

Abstract

OBJECTIVE: This report describes the increased risks of cordocentesisin fetuses affected with alloimmune thrombocytopenia. STUDY DESIGN: As part of a multicenter treatment study clinical and laboratory data from five pregnancies with alloimmune thrombocytopenia in which there was a fetal or neonatal loss associated with cordocentesis were reviewed. The fetal or neonatal deaths were all thought to be a result of exsanguination. These fetuses were compared with a group of 44 affected fetuses who underwent the same procedure but who survived. The data were analyzed by the Wilcoxon rank-sum test and the two-tailed Fisher's exact test. A p value < 0.05 was considered significant. RESULTS: The mean platelet count at cordocentesis was significantly lower in the cases than in the controls (5.8 vs 32.8 x 10(9)/L, p = 0.005). The incidence of antenatal intracranial hemorrhage in the untreated sibling of the prior affected pregnancy was significantly greater in the cases than in the controls (two of five vs one of 42, p = 0.02). CONCLUSION: Fetuses affected with alloimmune thrombocytopenia are at increased risk for fatal exsanguination associated with cordocentesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 09:37:24