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Titolo:
TRANSPLANTATION OF ISOLATED HEPATOCYTES AND THEIR ROLE IN EXTRAHEPATIC LIFE-SUPPORT-SYSTEMS
Autore:
DIXIT V;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,DEPT MED,LIVER BIOSUPPORT & HEPATITIS RES LAB,675 CIRCLE DR S LOS ANGELES CA 90024
Titolo Testata:
Scandinavian journal of gastroenterology
, volume: 30, anno: 1995, supplemento:, 208
pagine: 101 - 110
SICI:
0036-5521(1995)30:<101:TOIHAT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROCARRIER-ATTACHED HEPATOCYTES; HYBRID BIOARTIFICIAL LIVER; GUNN-RATS; MICROENCAPSULATED HEPATOCYTES; ARTIFICIAL CELLS; HEPATIC-FAILURE; HEPATOCELLULAR TRANSPLANTATION; ASSIST DEVICE; ANIMAL-MODEL; SPLEEN;
Keywords:
ARTIFICIAL LIVER SUPPORT; BIOARTIFICIAL LIVER; BRIDGE-TO-TRANSPLANTATION; CELL (HEPATOCYTE) TRANSPLANTATION; HEPATOCYTE BIOREACTOR; ISOLATED HEPATOCYTES; MICROENCAPSULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
V. Dixit, "TRANSPLANTATION OF ISOLATED HEPATOCYTES AND THEIR ROLE IN EXTRAHEPATIC LIFE-SUPPORT-SYSTEMS", Scandinavian journal of gastroenterology, 30, 1995, pp. 101-110

Abstract

Transplantation of isolated hepatocytes for the replacement of liver function and the use of isolated hepatocytes as a bridge-to-transplantation in extrahepatic bioartificial liver support devices offer important therapeutic advances for treating severe liver disease. Progress in cell biology, tissue culture techniques and biotechnology have led the way for the potential therapeutic use of isolated hepatocytes in a wide array of liver disorders. Transplanted hepatocytes show considerable promise of performing the full range of liver functions in severalanimal models of liver disease, ranging from fulminant hepatic failure to congenital metabolic liver disease. Recently, several interestingdesigns for extrahepatic liver support systems have been proposed. Although there is no current consensus on its eventual design configuration, the hollow fiber hepatocyte bioreactor design has the greatest potential for therapeutic benefit.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/21 alle ore 15:30:38