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Titolo:
ANTI-MULLERIAN HORMONE IN RELATION TO THE GROWTH AND DIFFERENTIATION OF THE GUBERNACULAR PRIMORDIA IN MICE
Autore:
LYET L; VIGIER B; VANDERSCHOOT P;
Indirizzi:
ERASMUS UNIV ROTTERDAM,FAC MED & HLTH SCI,DEPT ENDOCRINOL & REPROD NL-3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,FAC MED & HLTH SCI,DEPT ENDOCRINOL & REPROD NL-3000 DR ROTTERDAM NETHERLANDS ECOLE NORMALE SUPER,INSERM U293,UNITE RECH ENDOCRINOL DEV MONTROUGE FRANCE
Titolo Testata:
Journal of Reproduction and Fertility
fascicolo: 2, volume: 108, anno: 1996,
pagine: 281 - 288
SICI:
0022-4251(1996)108:2<281:AHIRTT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANDROGEN INSENSITIVITY SYNDROME; TESTICULAR DESCENT; INHIBITING SUBSTANCE; DUCT-SYNDROME; RAT GUBERNACULUM; RECEPTOR GENE; TESTIS; MUTATION; INVITRO; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
L. Lyet et al., "ANTI-MULLERIAN HORMONE IN RELATION TO THE GROWTH AND DIFFERENTIATION OF THE GUBERNACULAR PRIMORDIA IN MICE", Journal of Reproduction and Fertility, 108(2), 1996, pp. 281-288

Abstract

The present study analysed gubernaculum development in mice that had been induced, through transgenesis, to express human anti-Mullerian hormone (h-AMH) throughout prenatal life. Growth and differentiation of the gubernacular primordia were assessed through the analysis of serial, transverse or sagittal, histological sections of the lower abdomen. Transgenic males and females expressed biologically active amounts ofh-AMH as measured by sensitive and specific ELISA and evidenced through the regression, in females, of Mullerian ducts after day 13 of prenatal life. Gubernacular primordia became distinguishable at the same age in control and transgenic male and female fetuses on day 12 after coitus. In both groups gubernacular cords (inguinal folds of the genital mesenteries) increased in length more in females than in males, while gubernacular cones showed larger growth in males. h-AMH thus appeared not to affect the sexually dimorphic pattern of growth and development of these structures. Growth and differentiation of the gubernacularprimordia was further examined in 18-day-old control and h-AMH transgenic fetuses that had been exposed to testosterone propionate injectedinto their mothers on days 12 and 14 of pregnancy. Testosterone treatment affected, to a minor extent, the growth of the female gubernacular cords: these were reduced in length (but had a larger surface area) compared with controls. The gubernacular cones were slightly increasedin length but male-like differentiation of the tissues of the cones into a muscular and mesenchymal component was not noticed to any extent. The observations thus add experimental support to the contention that AMH, even in combination with testosterone, is not effective in establishing the male pattern of gubernacular primordia development.

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Documento generato il 04/12/20 alle ore 13:20:08