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Titolo:
DIFFERENTIATION OF THE OLFACTORY EPITHELIUM DURING DEVELOPMENT
Autore:
SAKASHITA H; MORIIZUMI T; ITO M; FURUKAWA M; KAWANO J; OKOYAMA S; KITAO Y; KUDO M;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT ANAT KANAZAWA ISHIKAWA 920 JAPAN KANAZAWA UNIV,SCH MED,DEPT ANAT KANAZAWA ISHIKAWA 920 JAPAN KANAZAWA UNIV,DEPT OTORHINOLARYNGOL KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
Acta oto-laryngologica
fascicolo: 1, volume: 115, anno: 1995,
pagine: 93 - 98
SICI:
0001-6489(1995)115:1<93:DOTOED>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPSE FORMATION; RAT FETUS; BULB; NEURON; MOUSE; NEUROGENESIS; MUCOSA; PROLIFERATION; POPULATIONS; MICROSCOPY;
Keywords:
OLFACTORY RECEPTOR CELLS; MATURITY; FLUORESCENT TRACER; DEGENERATION METHOD; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
H. Sakashita et al., "DIFFERENTIATION OF THE OLFACTORY EPITHELIUM DURING DEVELOPMENT", Acta oto-laryngologica, 115(1), 1995, pp. 93-98

Abstract

Maturation of the olfactory epithelium was studied in the rat. As a developmental index of the olfactory epithelium, quantitation was basedon the thickness and the number of cell layers of the epithelium. Mean epithelial thicknesses were 84 mu m on embryonic day (E) 19, 94 mu mon postnatal day (P) 0, 98 mu m on P10 and 57 mu m in adult. Average numbers of cell layers were 7 (E19), 8 (P0), 10 (P10) and 7 (adult). Thus the olfactory epithelium progressively increased in thickness between P0-P10, and later decreased in thickness as well as in number of cell layers toward adult. To clarify the number of mature receptor cells sending their axons to the olfactory bulb, the percentages of receptor cell labeling (number of labeled cells/total number of receptor cells) were estimated with an aid of retrograde fluorescent tracer injected into the olfactory bulb. As a result, their percentages were 34% (P1-P3), 50% (P8-P10) and 78% (adult). The ablation experiment of the bulb on P1 pups and adult rats revealed that the percentages of receptorcell degeneration were 31% in neonates (P1) and 76% in adults, confirming the results obtained from the retrograde tracing. Thus the present study shows the substantial increase of mature receptor cells duringdevelopment and may provide a morphological basis in understanding ofthe functional maturity of olfaction.

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Documento generato il 05/07/20 alle ore 22:13:43