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Titolo:
SYNTHESIS OF 1,3-DIHYDRO-3,3-DIMETHYL-2H-INDOL-2-ONE DERIVATIVES AS POSSIBLE NONSTEROIDAL CARDIOTONICS
Autore:
LEE AR; HUANG WH; LIN TL; SHIH KM; LEE HF; LIN CI;
Indirizzi:
NATL DEF MED CTR,SCH PHARM TAIPEI TAIWAN NATL DEF MED CTR,INST PHARMACOL TAIPEI TAIWAN
Titolo Testata:
Journal of heterocyclic chemistry
fascicolo: 1, volume: 32, anno: 1995,
pagine: 1 - 11
SICI:
0022-152X(1995)32:1<1:SO1DAP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITIVE INOTROPIC AGENTS; CONGESTIVE HEART-FAILURE; CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; RADICAL CYCLIZATION; AMP PHOSPHODIESTERASE; 6-)4-(1H-IMIDAZOL-1-YL)PHENYL>-3(2H)-PYRIDAZINONES; POTENT; 4,5,6-TETRAHYDRO-6-OXO-3-PYRIDAZINYL)-2H-INDOL-2-.; INHIBITOR; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A.R. Lee et al., "SYNTHESIS OF 1,3-DIHYDRO-3,3-DIMETHYL-2H-INDOL-2-ONE DERIVATIVES AS POSSIBLE NONSTEROIDAL CARDIOTONICS", Journal of heterocyclic chemistry, 32(1), 1995, pp. 1-11

Abstract

New substituted 1,3-dihydro-3,3-dimethyl-2H-indol-2-one derivatives 19-29 and 34-43 were synthesized and examined for their inotropic activity in isolated dog ventricular tissues. Among them, compound 26 ethoxybenzylamino)-N-(3,3,7-trimethyl-2-oxo-2,3??? dihydro-1H-indol-5-yl)acetamide) showed very potent activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 06:40:25