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Titolo:
BIOENERGETIC AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISEASES
Autore:
BOWLING AC; BEAL MF;
Indirizzi:
MASSACHUSETTS GEN HOSP,NEUROL SERV,WARREN 408 BOSTON MA 02114 MASSACHUSETTS GEN HOSP,NEUROL SERV BOSTON MA 02114 MASSACHUSETTS GEN HOSP,NEUROCHEM LAB BOSTON MA 02114 HARVARD UNIV,SCH MED BOSTON MA 02114
Titolo Testata:
Life sciences
fascicolo: 14, volume: 56, anno: 1995,
pagine: 1151 - 1171
SICI:
0024-3205(1995)56:14<1151:BAOSIN>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; MOTOR-NEURON DISEASE; SUPEROXIDE-DISMUTASE ACTIVITY; CYTOCHROME-C-OXIDASE; MITOCHONDRIAL RESPIRATORY-CHAIN; POSITRON EMISSION TOMOGRAPHY; TRANSGENIC DROSOPHILA-MELANOGASTER; ALPHA-KETOGLUTARATE DEHYDROGENASE; GLUTATHIONE-PEROXIDASE ACTIVITY; IDIOPATHIC PARKINSONS-DISEASE;
Keywords:
MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; ELECTRON TRANSPORT CHAIN; OXIDATIVE DAMAGE; FREE RADICALS; ALZHEIMERS DISEASE; PARKINSONS DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; HUNTINGTONS DISEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
256
Recensione:
Indirizzi per estratti:
Citazione:
A.C. Bowling e M.F. Beal, "BIOENERGETIC AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISEASES", Life sciences, 56(14), 1995, pp. 1151-1171

Abstract

Aging is a major risk factor for several common neurodegenerative diseases, including Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and Huntington's disease (HD). Recent studies have implicated mitochondrial dysfunction and oxidative stress in the aging process and also in the pathogenesis of neurodegenerative diseases. In brain and other tissues, aging is associated with progressive impairment of mitochondrial function and increased oxidative damage. In PD, several studies have demonstrated decreased complex Iactivity, increased oxidative damage, and altered activities of antioxidant defense systems. Some cases of familial ALS are associated withmutations in the gene for Cu, Zn superoxide dismutase (Cu, Zn SOD) and decreased Cu, Zn SOD activity, while in sporadic ALS oxidative damage may be increased. Defects in energy metabolism and increased cortical lactate levels have been detected in HD patients. Studies of AD patients have identified decreased complex IV activity, and some patients with AD and PD have mitochondrial DNA mutations. The age-related onsetand progressive course of these neurodegenerative diseases may be dueto a cycling process between impaired energy metabolism and oxidativestress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:28:15